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Human Genetics   Research Article

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population

Authors: S.G. Liu, L. Ma, Q.H. Cen, J.S. Huang, J.X. Zhang and J.J. Zhang

Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased ris.. Read More»

Genet. Mol. Res. 14(2):
2015.May.4.4
DOI:
10.4238/2015.May.4.4
Medical Genetics   Research Article

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

Authors: L.Q. Shen, Y.Z. Xie, X.F. Qian, Z.X. Zhuang, Y. Jiao and X.F. Qi

Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let- 7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes i.. Read More»

Genet. Mol. Res. 14(2):
2015.May.4.8
DOI:
10.4238/2015.May.4.8
Human Genetics   Research Article

Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts

Authors: P.K. Mishra A. Bhargava G.V. Raghuram S. Gupta S. Tiwari R. Upadhyaya S.K. Jain K.K. Maudar

Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as i.. Read More»

Genet. Mol. Res. 8(1):
vol8-1gmr544
DOI:
10.4238/vol8-1gmr544
Medical Genetics   Research Article

Computed tomography-guided percutaneous microwave ablation therapy for lung cancer

Authors: Y.H. Sun, P.Y. Song, Y. Guo and L.J. Sheng

This study evaluated the clinical efficacy and value of computed tomography (CT)-guided percutaneous microwave ablation therapy (PMAT) for lung cancer without surgical treatment. A total of 39 lesions in 29 patients with peripheral lung cancer were treated by CT-guided PMAT under local anesthesia. The microwave energy was 50-70 W at a frequency of 2450 MH.. Read More»

Genet. Mol. Res. 14(2):
2015.May.11.18
DOI:
10.4238/2015.May.11.18
Human Genetics   Research Article

Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China

Authors: Y. Fang, H.Y. Yang, Y.H. Shi, J.H. Cui, L.Y. Li, Y.C. Xu and J.L. Shao

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactorsin the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-.. Read More»

Genet. Mol. Res. 14(2):
2015.May.12.6
DOI:
10.4238/2015.May.12.6
Medical Genetics   Research Article

Predictive role of RRM1 and BRCA1 mRNA expression on the clinical outcome of advanced non-small cell lung cancer

Authors: J.G. Liang, Z.Y. Jin, X.D. Gao, M.R. Te, L.H. Ge and C.L. Wang

This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients in terms of their response and prognosis. In total, 377 patients agreed to participate in our study, and all of them received plati.. Read More»

Genet. Mol. Res. 13(3):
2014.July.24.8
DOI:
10.4238/2014.July.24.8
Human Genetics   Research Article

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Authors: F. Yan, R. Wang and L. Geng

Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible st.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038172
DOI:
10.4238/gmr.15038172
Human Genetics   Research Article

Clinical three-dimensional conformal radiotherapy research using repeated computed tomography scans for field reduction in older non-small-cell lung cancer patients

Authors: Z.Z. Fu, T. Gu, S.H. Zhang, X.Y. Cao, Q.H. Zhang, Y.Q. Zhang, H.X. Hua, S. Yang, P. Li and Z. Zhang

This study investigated the curative and toxic effects of three-dimensional conformal radiotherapy (3D-CRT), using repeated CT scans for field reduction in older non-small-cell lung cancer (NSCLC) patients. 3D-CRT was administered to 36 older patients with NSCLC, and irradiation fields included the primary lesion and metastati.. Read More»

Genet. Mol. Res. 13(3):
2014.July.24.13
DOI:
10.4238/2014.July.24.13
Human Genetics   Original Articles

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

Authors: H. Liu, H.F. Ma and Y.K. Chen

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform lit.. Read More»

Genet. Mol. Res. 14(1):
2015.February.13.17
DOI:
10.4238/2015.February.13.17
Human Genetics   Research Article

Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients

Authors: K.F. Ma, X.Y. Chu and Y. Liu

The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage I non-small cell lung cancer (NSCLC) patients. From January 2004 to December 2007, LVI was detected in 57 patients with T1N0M0 NSCLC; therefore, 114 patients with the same pathology, T stage, and surgery method, but without LVI, were se.. Read More»

Genet. Mol. Res. 14(1):
2015.March.13.10
DOI:
10.4238/2015.March.13.10