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Medical Genetics   Research Article

Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer

Authors: Y. Han, D.P. Yu, S.J. Zhou, X.Y. Song, Y.S. Li, N. Xiao, Z.D. Liu, X.J. Sun, Q.Y. Zhao and S.K. Liu.

More than 40 oncogenes associated with non-small cell lung cancer (NSCLC) have been identified with varied gene expression. The correlations between specific clinical characteristics and oncogene expression in NSCLC patients were examined. From October 2011 to September 2012, a total of 60 patients with NSCLC (male:female, 34:24; mean age, 59.5 ± 1.. Read More»

Genet. Mol. Res. 13(4):
Medical Genetics   Research Article

KDR gene silencing inhibits proliferation of A549cells and enhancestheir sensitivity to docetaxel

Authors: R. Wei and J.-P. Zang

We investigated the effects of kinase-domain insert containing receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to docetaxel. After designing and synthesizing the KDR siRNA sequence, the sequence was transfected into A549 cells using Lipofectamine 2000. The expression of KDR.. Read More»

Genet. Mol. Res. 14(4):
2015.November.18.43
DOI:
10.4238/2015.November.18.43
Medical Genetics   Research Article

Detection of CK19, LUNX, and KS1/4 mRNA expression in the peripheral blood for diagnosis of micrometastases in patients with non-small cell lung cancer and their clinical implications

Authors: L. Yan, Y. Yao, L.H. Wang, M.L. Wang and X.H. Fu

The expression of CK19, LUNX, and KS1/4 mRNA biomarkers was detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients to investigate the feasibility of indicating lung cancer micrometastases. Micrometastases were identified in the peripheral blood of 32 NSCLC patients, 15 benign pulmonar.. Read More»

Genet. Mol. Res. 14(4):
2015.November.24.17
DOI:
10.4238/2015.November.24.17
Human Genetics   Research Article

Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer

Authors: Y.F. Ma*, B. Yang*, J. Li, T. Zhang, J.T. Guo, L. Chen, M. Li, J. Chu,C.Y. Liang and Y. Liu

Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the relationship between Rab25 and chemotherapy sensitivity and prognosis in NSCLC. Rab25 expression was assessed using immunohistochemist.. Read More»

Genet. Mol. Res. 14(4):
2015.October.29.19
DOI:
10.4238/2015.October.29.19
Human Genetics   Research Article

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells

Authors: S.F. Chen, Z.Y. Zhang and J.L. Zhang

It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATP‑binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in the o.. Read More»

Genet. Mol. Res. 14(4):
2015.November.18.18
DOI:
10.4238/2015.November.18.18
Human Genetics   Research Article

Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations

Authors: L. Xu, J. Lei, Q.Z. Wang, J. Li and L. Wu

Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients w.. Read More»

Genet. Mol. Res. 14(4):
2015.October.21.18
DOI:
10.4238/2015.October.21.18
Medical Genetics   Research Article

Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR

Authors: M. Ding, X. Li and T. Qiu

Our study aims to determine the clinical significance of human telomerase reverse transcriptase (hTERT), S-phase kinase-associated protein 2 (Skp2) and thyroid transcription factor-1 (TTF-1) mRNA expressions in peripheral blood (PB) of patients with non-small cell lung cancer (NSCLC). Real-time polymerase chain reaction was used to investigate the gene ex.. Read More»

Genet. Mol. Res. 14(4):
2015.October.21.24
DOI:
10.4238/2015.October.21.24
Human Genetics   Research Article

Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

Authors: J. Li, X.F. Jia, J. Liu, J.J. Liu and H.B. Zhao

The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in ca.. Read More»

Genet. Mol. Res. 14(4):
2015.October.5.5
DOI:
10.4238/2015.October.5.5
Medical Genetics   Research Article

Correlation between expression and significance of δ-catenin, CD31, and VEGF of non-small cell lung cancer

Authors: X.L. Liu, L.D. Liu, S.G. Zhang, S.D. Dai, W.Y. Li and L. Zhang

We analyzed the expression and clinical significance of δ-catenin in non-small cell lung cancer (NSCLC) and investigated prognosis using human lung cancer samples. Eighty-nine NSCLC patients underwent operation between January and March 2009. There were 53 cases of squamous cell carcinoma, 31 adenocarcinoma, and 5 large cell carcinoma. δ-Caten.. Read More»

Genet. Mol. Res. 14(4):
2015.October.28.10
DOI:
10.4238/2015.October.28.10
Human Genetics   Research Article

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

Authors: H. Wang Y. Zhao J. Ma G. Zhang Y. Mu G. Qi Z. Fang L. Wang Q. Fan Z. Ma

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms pr.. Read More»

Genet. Mol. Res. 12(1):
2013.January.22.5
DOI:
10.4238/2013.January.22.5