Lung Adenocarcinoma
The exploration of potential relationship between COPD and LUAD based on single-cell sequencing and bulk transcriptome sequencing
Authors: Yanjiao Zhang*, Yicheng Liang
Background: Lung Adenocarcinoma (LUAD) and Chronic Obstructive Pulmonary Disease (COPD) are lung diseases that may share some common etiological factors and mechanisms. Epithelial-Mesenchymal Transition (EMT) plays an essential role in regulating numerous physiological and pathological processes. This study aimed to evaluate potential rel.. Read More»
- Genet. Mol. Res. 24(1):
Effects of kinase insert domain receptor (KDR) gene silencing on the sensitivity of A549 cells to erlotinib
Authors: W.L. Zhu and Y.H. Liu
We investigated the effects of kinase insert domain receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to erlotinib. A KDR small interfering RNA (siRNA) sequence was designed and synthesized; then, it was transfected into A549 cells using LipofectamineTM 2000. KDR mRNA and protein expression after KDR gene si.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.15
- DOI:
- 10.4238/2015.November.24.15
JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
Authors: X. Liu, Y. Sun, L. Yue, S. Li, X. Qi, H. Zhao, Y. Yang, C. Zhang and H. Yu
Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner byactivating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039003
- DOI:
- 10.4238/gmr.15039003
Diagnosis of lymph node micrometastasis at the pN0 stage of lung adenocarcinoma using a combination of markers
Authors: H. Liu, Y.-K. Ye, G.-M. Li, Y. Zhou, K.-B. Han, G. Xu and D. Wang
This study aimed to detect micrometastatic tumor cells in the lymph nodes of patients with pN0 lung adenocarcinoma using a combination of thyroid transcription factor-1 (TTF-1) expression and cytokeratin 7 (CK7) expression and to investigate the association of lymph node micrometastasis with the clinicopathological characteris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.14
- DOI:
- 10.4238/2014.July.25.14
Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma
Authors: X.F. Chen, S. Cai, Q.G. Chen, Z.H. Ni, J.H. Tang, D.W. Xu and X.B. Wang
Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.16.2
- DOI:
- 10.4238/2012.February.16.2
Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples
Authors: Y. Guan, Z.J. Wang, L.Q. Wang, D.F. Hua and J. Liu
The goal of the current study was to investigate the differences in epidermal growth factor receptor (EGFR) mutation rates in tumor tissue and pleural effusion specimens from patients with lung adenocarcinoma. PCR amplification and gene sequencing were used to detect EGFR mutations in exons 18, 19, 20, and 21 in tumor tissue a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027001
- DOI:
- 10.4238/gmr.15027001
Genome-scale meta-analysis of DNA methylation during progression of lung adenocarcinoma
Authors: Q.H. Zhang, X.H. Dai, Z.M. Dai and Y.N. Cai
Identification of epigenetic alterations in tumors has become a common method for identifying genes critical to cancer development and progression. Thus, we identified DNA methylation alterations on the genome scale during lung adenocarcinoma (LADC) progression to understand the carcinogenic process and identify clinically relevant biomarkers. We found th.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.30
- DOI:
- 10.4238/2015.August.7.30
Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance
Authors: X. Yu, Y. Li, S.W. Chen, Y. Shi and F. Xu
In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.2
- DOI:
- 10.4238/2015.August.28.2
Correlation between matrix metalloproteinase-9 and vascular endothelial growth factor expression in lung adenocarcinoma
Authors: Y.L. Wen and L. Li
The aim of this study was to investigate the correlation between the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) and clinicopathological features of lung adenocarcinoma. The expression of MMP-9 and VEGF was evaluated by immunohistochemistry of 30 samples from lung adenocarcinoma patients and 12 paratumora.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.44
- DOI:
- 10.4238/2015.December.29.44