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Human Genetics   Research Article

Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

Authors: Shaobing Wang, Zhenghong Zhang, Yiping Liu, Zhengchao Wang

Prediabetes is considered to be an at a risk state, with an annualized 5-10% conversion rate of diabetes and the similiar proportion converting back to normoglycaemia. The global incidence of prediabetes is increasing and will reach to 471 million patients in 2030. The elevation of blood sugar is a continuum and hence prediabe.. Read More»

Genet. Mol. Res. 16(4):
Human Genetics   Research Article

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

Authors: S.B. Lecke, D.M. Morsch and P.M. Spritzer

We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and.. Read More»

Genet. Mol. Res. 12(4):
Human Genetics   Research Article

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Authors: F.J. Wei, C.Y. Cai, P. Yu, J. Lv, C. Ling, W.T. Shi, H.X. Jiao, B.C. Chang, F.H. Yang, Y. Tian, M.S. Li, Y.H. Wang, L. Zou, J.M. Shi, L.M. Chen and W.D. Li

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single.. Read More»

Genet. Mol. Res. 14(4):
Human Genetics   Research Article

Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain injury

Authors: R. Zhang1, Z.Y. Wang1, L.L. Zhu1, F. Wu1, D.Q. Chen1, L.F. Sun1 and Z.Q. Lu2

Resistin (RSTN) expression in subcutaneous adipose tissue, and its effect on glucose metabolism in rats with traumatic brain injury, was investigated using real-time PCR, western blots, and enzyme linked immunoassays. Our results show that the expression of RSTN mRNA (3.192 ± 0.046, 4.016 ± 0.010, 6.004 ± 0.020, 8.213 ± 0.013, .. Read More»

Genet. Mol. Res. 15(1):
Human Genetics   Research Article

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity

Authors: M.Y. Zhang, F. Li and J.P. Wang

Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate.. Read More»

Genet. Mol. Res. 16(2):
Human Genetics   Research Article

TNF-α G-308A polymorphism is associated with insulin resistance: a meta-analysis

Authors: H.G. Wang, J. Yang, H. Han, F. Xu, Y. Bian, H. Zhang and J.L. Wang

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE an.. Read More»

Genet. Mol. Res. 14(1):
Human Genetics   Research Article

Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes

Authors: L. Yang, S.J. Chen, G.Y. Yuan, D. Wang and J.J. Chen

We investigated serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes (T2DM) and explored the association between vaspin and body mass index, age, gender, glucose, lipid metabolism, and insulin sensitivity. Fasting serum vaspin levels in 66 patients with T2DM and 48 n.. Read More»

Genet. Mol. Res. 14(2):
Human Genetics   Research Article

Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in an Indian population

Authors: P.N. Mukhopadhyaya, A. Acharya, Y. Chavan, S.S. Purohit and A. Mutha

A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females)... Read More»

Genet. Mol. Res. 9(4):
Medical Genetics   Research Article

Role of APN and TNF-α in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease

Authors: X. Lin, Z. Zhang, J.M. Chen, Y.Y. Xu, H.R. Ye, J. Cui, Y. Fang,Y. Jin, D.R. Zhu and L. Yuan

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-a (TNF-a) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resis.. Read More»

Genet. Mol. Res. 14(2):
Medical Genetics   Research Article

Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes

Authors: W.R. Bi, C.Q. Yang, Q. Shi, Y. Xu, C.P. Cao, J. Ling and X.Y. Wang

Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was.. Read More»

Genet. Mol. Res. 13(3):