All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Human Genetics   Research Article

Differential expression of trypsin-3 and phosrestin II genes in the main malaria vector, Anopheles darlingi, from the Brazilian Amazon region

Authors: Ohse, K.C, Matiolli, C.C, Scarpassa, V.M, Santos, V. S, Tadei, W. P, Rafael, M. S

Anopheles darlingi is the most anthropophilic mosquito related to Plasmodium infection of malaria, causing significant morbidity and mortality in South America. Pyrethroid chemical has been used to control mosquitos. We analyzed the expression of trypsin-3 and phosrestin II genes implicated to feeding and resistance to insecti.. Read More»

Genet. Mol. Res. 16(4):
gmr16039852
DOI:
10.4238/gmr16039852
Human Genetics   Research Article

Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus

Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang

We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»

Genet. Mol. Res. 13(1):
2014.January.3.1
DOI:
10.4238/2014.January.3.1
Microbial Genetics   Research Article

Elucidating the function and tolerance mechanism of gamma delta (γ δ) T cells in a Helicobacter pylori infection model

Authors: T.E. Chen, X.M. Xu, P. Liu, S.Y. Liang and W.X. Lv

In this study, the functions and mechanisms of γ δ T cells were analyzed in patients infected with Helicobacter pylori. Peripheral blood was collected from gastritis patients in the Gastroenterology Department of Ningbo No. 2 Hospital. Preliminary analyses revealed 24 H. pylori-positive and 17 H. pylori-negative patients. The wild-type and &ga.. Read More»

Genet. Mol. Res. 14(3):
http://dx.doi.org/2015.September.8.16
DOI:
http://dx.doi.org/10.4238/2015.September.8.16
Medical Genetics   Research Article

Prominent contribution of Th1, Th17, and Tregs to the host response during M. neoaurum infection

Authors: C.F. Wang, W.T. Yang, L.M. Yue, J.Y. Qiu, L.J. Zhang, C. Wang, X.Y. Jiang and A.D. Qian

Nontuberculous mycobacteria are ubiquitous in outside environment and animals. As for nontuberculous mycobacteria infection, there is only limited information in humans regarding infection and the subsequent immune response, especially for Mycobacterium neoaurum. Here, haematoxylin-eosin and Ziehl-Neelsen staining were used to observe pathological changes.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038989
DOI:
10.4238/gmr.15038989
Plant Genetics   Research Article

Molecular characterization and expression analysis of purple acid phosphatase gene from pearl oyster Pinctada martensii

Authors: Q.H. Wang, Y. Jiao, X.D. Du, X.X. Zhao, R.L. Huang,Y.W. Deng and F. Yan

Purple acid phosphatases (PAPs), also known as type 5 acid phosphatases, are widely present in animals, plants, and fungi. In mammal, PAP was reported to participate in immune defense and bone resorption. In this study, the characteristics and potential functions of a PAP gene from pearl oyster Pinctada martensii (pm-PAP) were examined. The Pm-PAP cDNA wa.. Read More»

Genet. Mol. Res. 14(1):
2015.January.26.10
DOI:
10.4238/2015.January.26.10
Animal Genetics   Research Article

Molecular characterization and expression patterns of the big defensin gene in freshwater mussel (Hyriopsis cumingii)

Authors: G.-L. Wang, X.-L. Xia, X.-L. Li, S.-J. Dong and J.-L. Li

Antimicrobial peptides (AMPs), of which big defensins are examples, are an important component of the natural defenses of most living organisms, and possess remarkable microbicidal activities. In the present study, using expressed-sequence tag sequences from a cDNA library and RACE, the full-length cDNA sequence of the big def.. Read More»

Genet. Mol. Res. 13(1):
2014.January.29.1
DOI:
10.4238/2014.January.29.1
Animal Genetics   Research Article

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers

Authors: F.X. Wei, X.F. Hu, B. Xu, M.H. Zhang, S.Y. Li, Q.Y. Sun and P. Lin

To investigate the effect of ammonia (NH3) and humidity on the immune response of broilers, broilers were exposed to 30 or 70 mg/kg atmospheric NH3 for 21 days. Additionally, birds were exposed to 35, 60, and 85% relative humidity (RH). The relative weights of lymphoid organs, serum total protein, serum globulin, serum albumin, serum lysozyme, proliferati.. Read More»

Genet. Mol. Res. 14(2):
http://dx.doi.org/2015.April.10.27
DOI:
http://dx.doi.org/10.4238/2015.April.10.27
Medical Genetics   Research Article

Proteome analysis of the liver in the Chinese fire-bellied newt Cynops orientalis

Authors: X.Y. Zang, J.L. Guo1, X.F. Geng, P.F. Li, J.Y. Sun, Q.W. Wang and C.S. Xu

The Chinese fire-bellied newt, Cynops orientalis, belonging to Amphibia, Caudata, Salamandridae is a species endemic to China. The liver, which is an important digestive gland and the largest amphibian organ, has various functions, including detoxification, glycogen storage, protein synthesis, and hormone production. However, the newt liver has rarely bee.. Read More»

Genet. Mol. Res. 15(3):
gmr.15037993
DOI:
10.4238/gmr.15037993
Animal Genetics   Research Article

Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model

Authors: Q.-F. Gui, H.-F. Lu, C.-X. Zhang, Z.-R. Xu and Y.-M. Yang

The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the anti.. Read More»

Genet. Mol. Res. 14(2):
2015.May.25.16
DOI:
10.4238/2015.May.25.16
Medical Genetics   Research Article

Molecular cloning and immune response analysis of putative variable lipoproteins from Mycoplasma mycoides subsp capri

Authors: C.G. Xu, Y.Q. Hao, L. Zhang, R.X. Hao, X.L. Liu and Z.Y. Huang

Mycoplasma mycoides subsp capri is the cause of goat “MAKePS” (Mastitis, Arthritis, Keratoconjunctivitis, Pneumonia, Septicemia) syndrome. We identified three genes (GL_ 000459; 000461; 000462) as variable lipoprotein genes in the M. mycoides subsp capri str. PG3 genome by genomic information and comparative genomi.. Read More»

Genet. Mol. Res. 13(1):
http://dx.doi.org/2014.March.12.5
DOI:
http://dx.doi.org/10.4238/2014.March.12.5