Hepatitis B Virus
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population
Authors: V.R.Z.B. Pereira, J.M. Wolf, G.Z. Stumm, T.R. Boeira, J. Galvan, D. Simon and V.R. Lunge
Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029565
- DOI:
- 10.4238/gmr16029565
Construction and functional identification of a hepatitis B virus S protein small hairpin RNA recombinant adenovirus
Authors: S. Wang, Y.Z. Liu, D.D. Qin, C.C. Zou, Y.R. Sheng A.L. Huang and H. Tang
Hepatitis B virus S protein (HBs) plays an important role in hepatocellular carcinoma progression. However, to date, no direct and effective methods exist to research the function of HBs. Here, we combined the technology of RNA interference with recombinant adenovirus, constructed a recombinant adenovirus-expressing small hair.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.25.4
- DOI:
- 10.4238/2014.February.25.4
RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population
Authors: A. Al-Qahtani, S. Alarifi, M. Al-Okail, Z. Hussain4, A. Abdo, F. Sanai, M. Al-Anazi, N. Khalaf, H. Al-Humaidan, M. Al-Ahdal and F.N. Almajhdi
Besides the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. “Regulated on activation normal T-cell expressed and secreted” factor (RANTES) plays a vital role in CD4+, CD8+ T-lymphocyte and dendritic cell activation and proliferati.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.1
- DOI:
- 10.4238/2012.April.10.1
A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies
Authors: Y. Xiang, P. Chen, J.R Xia and L.P. Zhang
Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019102
- DOI:
- 10.4238/gmr16019102
Efficacy and safety of nucleoside analogues in preventing vertical transmission of the hepatitis B virus from father to infant
Authors: L.-H. Cao,P.-L. Zhao,Z.-M. Liu,S.-C. Sun,D.-B. Xu,J.-D. Zhang,Z.-H. Shao
We examined the efficacy and safety of nucleoside analogues in preventing the vertical transmission of hepatitis B virus (HBV) from father to infant. We included 201 patients who visited the liver clinic of our hospital. The patients were positive for HBV surface antigen (HBsAg), HBeAg, anti-HBc, and HBV DNA; 189 patients (94%.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.4
- DOI:
- 10.4238/2015.December.1.4
Stable expression and integrated hepatitis B virus genome in a human hepatoma cell line
Authors: L.Y. Wang, Y.G. Li, K. Chen, K. Li, J.L. Qu, D.D. Qin and H. Tang
HepG2.2.15 cell is a widely used cell model for studying HBV (hepatitis B virus) in vitro. In these cells, the HBV genome is integrated in several sites of HepG2 cellular DNA. These multiple copies may have some influence on the cellular processes. We constructed a new plasmid, pSEH-Flag-HBV, and transfected it into HepG2 cell.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.3
- DOI:
- 10.4238/2012.May.18.3
Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo
Authors: M.C. Zhu,C.G. Liu, D.X. Wang,Z. Zhan
We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.19
- DOI:
- 10.4238/2015.December.7.19
Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening
Authors: Y. Cui, T. Zhang, Y. Yan and K. Liu
Hepatitis B virus (HBV) infection can cause HBV-related cirrhosis, liver failure, and hepatocellular carcinoma. At present, a hepatitis B surface antigen (HBsAg) blood test is the primary clinical and diagnostic marker for the identification of a chronic HBV infection. In the current study, we isolated a novel HBV mutant from a chronic HBV patient, capabl.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037582
- DOI:
- 10.4238/gmr.15037582
Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania
Authors: E. Marku, P.E. Maltese, M. Koni, N. Capodicasa, I.S. Qendro, E. Rigoni, S. Cecchin and M. Bertelli
Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.13
- DOI:
- 10.4238/2015.May.18.13
Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro
Authors: Y.-B. Deng, H.-J. Qin, Y.-H. Luo, Z.-R. Liang and J.-J. Zou
The aim of this study was to investigate the effects of inhibition of the hepatitis B virus (HBV) S gene by polypurine region locked nucleic acid on viral replication in cells. We designed and synthesized a locked nucleic acid, phosphorothioate oligonucleotides, unmodified oligonucleotides, and unrelated control sequence for the hepatitis B virus S gene p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.14
- DOI:
- 10.4238/2015.May.22.14