Hepatitis B Virus
Establishment of reference sequences of hepatitis B virus genotype C subgenotypes
Authors: H.L. Zhu, C.T. Wang, J.B. Xia, X. Li and Z.H. Zhang
Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. W.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus
Authors: Y. Hu, W.L. Zhang, S.L. Xie, Y. Zhao, J.L. Hu, X.F. Cai, G.Q. Lai and A.L. Huang
Early detection of adefovir dipivoxil-resistant mutants during long-term treatment of chronic hepatitis B virus (HBV) infection with this drug is of great clinical importance. We developed an improved reverse dot hybridization test for simple and rapid detection of the rtA181V/T and rtN236T mutations associated with adefovir d.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.6
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.6
-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population
Authors: Z.S. Wang, C.C. Yin, S. Han, F.L. Jiang, W.G. Guo, L.Q. Wu and S.H. Liu
In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.23
- DOI:
- 10.4238/2015.July.28.23
Immune memory responses to HBV vaccine 13-18 years after primary vaccination
Authors: L. Hou, W. Li, X. Wei, Y. Zhou, Y. Zhuo, H. Wu, B. Shen
The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononu.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.14
- DOI:
- 10.4238/2015.July.28.14
Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma
Authors: M.W. Peng, S.Q. Lu, J. Liu and C.Y. Dong
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain r.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017984
- DOI:
- 10.4238/gmr.15017984
Synonymous codon selection in the hepatitis B virus translation initiation region
Authors: M.-R. Ma, L. Hui, M.-L. Wang, Y. Tang, Y.-W. Chang, Q.-H. Jia, X.-P. Yang, X.-H. Wang and X.-Q. Ha
Hepatitis B virus (HBV) infection is a major health problem worldwide. This virus and its hosts are often fated to continual co-evolutionary interactions. Codon usage analysis has significance for studies of co-evolution between viruses, their hosts, and mRNA translation. Adaptation of the overall codon usage pattern of HBV to that of humans is estimated .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.4
- DOI:
- 10.4238/2015.August.7.4
Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways
Authors: L.M. Wen, W.Z. Wu and X.C. Peng
This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from backgroun.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028343
- DOI:
- 10.4238/gmr.15028343
Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo
Authors: Y.B. Deng, H.J. Qin, Y.H. Luo, Z.R. Liang and J.J. Zou
We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.16
- DOI:
- 10.4238/2015.August.21.16
Correlation between hepatitis B virus DNA levels and diagnostic tests for HBsAg, HBeAg, and PreS1-Ag in chronic hepatitis B
Authors: X. Liu, J.M. Chen, J.L. Lou, Y.X. Huang, Y. Yan, G.Z. Sun and N. Li
he aim of this study was to investigate the diagnostic value of the serum markers HBsAg and HBeAg and PreS1 protein (PreS1-Ag) in quantifying the levels of hepatitis B virus (HBV) DNA in patients with chronic hepatitis B (CHB). One thousand CHB patients were recruited from Beijing You’an Hospital between June and Decembe.. Read More»
- Genet. Mol. Res. 15(2):