Hepatic Stellate Cells
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039818
- DOI:
- 10.4238/gmr16039818
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism
Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039818
- DOI:
- 10.4238/gmr16039818
High levels of glucose promote the activation of hepatic stellate cells via the p38-mitogen-activated protein kinase signal pathway
Authors: L.K. Wu, Y.C. Liu, G. Ma, L.L. Shi and X.M. He
The relationship between the p38-mitogen-activated protein kinase (p38-MAPK) signal pathway and high glucose-induced hepatic stellate cell (HSC) activation was investigated in this study. Sixty human HSC samples were randomly selected and used in the control (cultured normally), high-glucose (cultured in the presence of high g.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038419
- DOI:
- 10.4238/gmr.15038419
Effect of bone marrow mesenchymal stem cells on the TGF-�²1/Smad signaling pathway of hepatic stellate
Authors: X.E. Sun, X.Q. Zhang and M.M. Liu
This study investigated the effect of bone marrow mesenchymal stem cells (BMCs) on the transforming growth factor-β1 (TGF-b1)-induced activation of the Smad signaling pathway in rat hepatic stellate cells (HSCs). There were four experimental groups: 1) a blank control group, 2) a TGF-b1 treatment group, 3) an MSC-combined group, and 4) an induced MSC.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.23
- DOI:
- 10.4238/2015.July.31.23