Gene
G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals
Authors: L.L. Gao, X. Ding, D.M. Xie, M. Yang and B.R. Dong
The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We include.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.22
- DOI:
- 10.4238/2015.November.30.22
Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients
Authors: F.J. Wei, C.Y. Cai, P. Yu, J. Lv, C. Ling, W.T. Shi, H.X. Jiao, B.C. Chang, F.H. Yang, Y. Tian, M.S. Li, Y.H. Wang, L. Zou, J.M. Shi, L.M. Chen and W.D. Li
Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.25
- DOI:
- 10.4238/2015.November.30.25
Association between the interleukin-6 -174 G/C polymorphism and risk of ischemic stroke: a meta-analysis
Authors: X.F. Jin, D.L. Wang2, Y. Zhou and H. Xiong
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase da.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.3
- DOI:
- 10.4238/2015.October.26.3
729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer
Authors: B. Wan, J. Tan, Q. Zeng, L.Y. He, Y. Gan, Y.B. Dai and K. Yao
In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.26
- DOI:
- 10.4238/2015.November.30.26
RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer
Authors: S. SuÃ?¡rez-Villanueva, M.L. Ayala-Madrigal, J. Peregrina-Sandoval, N. MacÃ?Âas-GÃ?³mez, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz-Mendoza, J.M. Moreno-Ortiz, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, E. Cabrales and M. GutiÃ?©rrez-Angulo
We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.28
- DOI:
- 10.4238/2015.November.30.28
Molecular characterization, tissue distribution, and immune reaction expression of karyopherins in the domestic silkworm (Bombyx mori)
Authors: J. Li, L. Wang, C. Qian, C.F. Zhang, L.S. Dai, Q.N. Liu, G.Q. Wei, Y. Sun, D.R. Liu, B.J. Zhu and C.L. Liu
Karyopherins, including alpha and beta types, are transport proteins in the eukaryotic cell that carry cargoes across nuclear pore complexes into or out of the nucleus. In this study, full open reading frames of one beta and three alpha types of karyopherin were cloned from cDNA of the domestic silkworm (Bombyx mori). The one beta and three alpha types&rs.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.1
- DOI:
- 10.4238/2015.October.26.1
Analysis of upland cotton (Gossypium hirsutum) response to Verticillium dahliae inoculation by transcriptome sequencing
Authors: B.X. Shao, Y.L. Zhao, W. Chen, H.M. Wang, Z.J. Guo, H.Y. Gong, X.H. Sang, Y.L. Cui and C.H. Wang
Verticillium wilt is one of the main diseases in cotton (Gossypium hirsutum), severely reduces yield and fiber quality, and is difficult to be controlled effectively. At present, the molecular mechanism that confers resistance to this disease is unclear. Transcriptome sequencing is an important method to detect resistance genes, explore metabolic pathways.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.8
- DOI:
- 10.4238/2015.October.26.8
Comparison of gSSR and EST-SSR markers for analyzing genetic variability among tomato cultivars (Solanum lycopersicum L.)
Authors: R. Zhou, Z. Wu, F.L. Jiang and M. Liang
In order to study genetic variability and develop better strategies for the utilization of 48 tomato cultivars from America, China, the Netherlands, and Portugal, genomic simple sequence repeat (gSSR) and EST-derived SSR (EST-SSR) markers were applied. In all, 15 of 82 gSSR and 18 of 115 EST-SSR markers showed polymorphic loci. There were 995 and 2072 cle.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.14
- DOI:
- 10.4238/2015.October.26.14
Genetic mechanism associated with congenital cytomegalovirus infection and analysis of effects of the infection on pregnancy outcome
Authors: J.M. Li, H.F. Zhang, X.Q. Zhang, G.L. Huang, H.Z. Huang and W.W. Yu
We aimed to compare the diagnostic value of various detection methods for cytomegalovirus (CMV) infection, to investigate the genetic mechanism associated with CMV infection in pregnant women, and to analyze the risk of sequelae development in fetuses with CMV infection. A total of 300 participants who had the same immunosuppressive regimen and received p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.21
- DOI:
- 10.4238/2015.October.26.21
Cloning and transformation of INDUCER of CBF EXPRESSION1 (ICE1) in tomato
Authors: X.H. Yu, J.X. Juan, Z.L. Gao, Y. Zhang, W.Y. Li and X.M. Jiang
The tomato plant (Solanum lycopersicum Mill.) is sensitive to cold, and low field temperatures can result in shortened growth periods and decreased crop yield. Transcription of CRT/DRE-binding factor (CBF) is regulated by INDUCER of CBF EXPRESSION1 (ICE1). CBF activates many downstream genes that confer cold tolerance on plants. ICE1 has been used in gene.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.9
- DOI:
- 10.4238/2015.October.26.9