Gene
Bayesian forecasting of temporal gene expression by using an auto regressive panel data approach
Authors: M. Nascimento, F.F. e Silva, T. S�¡fadi, A.C.C. Nascimento, L.M.A. Barroso, L.S. Gl�³ria and B. de S. Carvalho
We propose and evaluate a novel approach for forecasting gene expression over non-observed times in longitudinal trials under a Bayesian viewpoint. One of the aims is to cluster genes that share similar expression patterns over time and then use this similarity to predict relative expression at time points of interest. Express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027299
- DOI:
- 10.4238/gmr.15027299
Anti-prostate cancer effects of CTL cell induction in vitro by recombinant adenovirus mediated PSMA/4-1BBL dendritic cells: an immunotherapy study
Authors: C.-G. Sui, D. Wu, F.-D. Meng, M.-H. Yang and Y.-H. Jiang
This study aimed to examine anti-prostate cancer immune response induced by dendritic cells (DCs) transduced with PSMA/4-1BBL recombinant adenoviruses in vitro. Ad-PSMA, Ad-4- 1BBL, and Ad-GFP were transfected into DCs derived from peripheral blood of healthy volunteers. Ad-PSMA/4-1BBL-DC, Ad-PSMA-DC, Ad-4-1BBL-DC, Ad-GFP-DC, and normal-DC, PSMA and 4-1BB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.14
- DOI:
- 10.4238/2015.June.29.14
Potential hippocampal genes and pathways involved in Alzheimer�s disease:a bioinformatic analysis
Authors: L. Zhang, X.Q. Guo, J.F. Chu, X. Zhang, Z.R. Yan and Y.Z. Li
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly people. Numerous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four t.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.15
- DOI:
- 10.4238/2015.June.29.15
RUNX3 promoter methylation correlation with pathogenesis of hepatocellular carcinoma in Asians
Authors: W. Lu, Y. Liu, L-L. Liu and P.-H. Zhuang
The aim of this study was to elucidate the role of RUNX3 promoter methylation in the pathogenesis of hepatocellular carcinoma (HCC) among Asians. For this purpose, we performed a comprehensive search of Chinese and English language scientific literature databases using stringent selection criteria; ultimately, we identified re.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027444
- DOI:
- 10.4238/gmr.15027444
Identification of SNPs within the PRLR gene and effects on maternal behavior in sheep
Authors: L.P. Wang, R.Q. Geng, X.N. Zhang and W. Sun
The prolactin receptor gene (PRLR) plays an essential role in maternal behavior. The aim of the study was to detect PRLR mutations in exon 10, using a polymerase chain reaction-single stranded conformation polymorphism method, and to determine the association between mutations in this region with maternal behavior traits in Chinese Hu sheep. Polymorphisms.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.26
- DOI:
- 10.4238/2015.December.21.26
Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta
Authors: Z. Yang, Z.F. Ke, C. Zeng, Z. Wang, H.J. Shi and L.T. Wang
Osteogenesis imperfecta is normally caused by an autosomal dominant mutation in the type I collagen genes COL1A1 and COL1A2. The severity of osteogenesis imperfecta varies, ranging from perinatal lethality to a very mild phenotype. Although there have been many reports of COL1A1 and COL1A2 mutations, few cases have been report.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr984
- DOI:
- 10.4238/vol10-1gmr984
SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population
Authors: H.Y. Li, Y.C. Liu, Y.H. Bai, M. Sun, L. Wang, X.B. Zhang and B. Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027735
- DOI:
- 10.4238/gmr.15027735
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira2, J.C. Silva Junior and A.A.L. Barbosa
The bs mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the geneti.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017604
- DOI:
- 10.4238/gmr.15017604
Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data
Authors: B. Wang, T. Wang, X.L. Cao and Y. Li
In this study, bioinformatic analysis of gene expression data of head and neck squamous cell carcinoma (HNSCC) was performed to identify critical genes. Gene expression data of HNSCC were downloaded from the Cancer Genome Atlas (TCGA) and differentially expressed genes were determined through significance analysis of microarrays. Protein-protein interacti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.10
- DOI:
- 10.4238/2015.December.21.10
Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese
Authors: T.Q. Zhou, H.J. Guan and J.Y. Hu
The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.13
- DOI:
- 10.4238/2015.December.21.13