Enos
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Authors: T.R. Santos, K.S.F. e Silva, R.C.P.C. Silva, K.K.V.O. Moura, L.A. Guillo, C.L. Ribeiro J�ºnior and I.R. Costa
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tiss.. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18046
- DOI:
- http://dx.doi.org/10.4238/gmr18046
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism
Authors: A.M. Barbosa, K.S.F. Silva, M.H. Lagares, D.A. Rodrigues,I.R. da Costa, M.P. Morais, J.V.M. Martins, R.S. Mascarenhas, F.L. Campedelli and K.K.V.O. Moura
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening cli.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039708
- DOI:
- 10.4238/gmr16039708
Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease
Authors: K. Zhou, Y. Wang, W. Peng, J. Sun, Y.M. Qing and X.M. Mo
The endothelial NO synthase (eNOS) enzyme is expressed during the early stages of cardiogenesis and plays an important role in normal heart development. Genetic variations of eNOS G894T have been shown to influence individual susceptibility to some phenotypes of congenital heart disease (CHD) in different populations. We condu.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.4
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
More severe clinical course of cardiovascular dysfunction in intensive care unit patients with the 894TT eNOS genotype
Authors: L.R. Fraga F.J.O. Paludo A.J.G. B�³s J.L.S. Ferraro F.S. Dias C.S. Alho
The endothelial nitric oxide synthase (eNOS) plays an important homeostatic role in the cardiovascular system (CVS) by maintaining appropriate blood pressure through production of nitric oxide. The 894TT genotype of 894G>T (Glu298Asp, rs1799983), a polymorphic variant of eNOS, has been associated with several vascular diseases. On the basis of this str.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.5
- DOI:
- 10.4238/2013.February.27.5
New sources of resistance to leafminers (Liriomyza sativae) in melon (Cucumis melo L.) germplasm
Authors: E.F. Celin, F.I.C. Oliveira, N.S. Dias-Pini, G.H.S. Nunes and F.A.S. Arag�£o
Leafminers (Liriomyza sativae) are the main melon (Cucumis melo L.) pests in Northeast Brazil, which is the main region for the production and export of the fruit in Brazil. Of the integrated management strategies available, genetic resistance is the best method of preventing damage by these insects. The aim of this study was .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029561
- DOI:
- 10.4238/gmr16029561
JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
Authors: X. Liu, Y. Sun, L. Yue, S. Li, X. Qi, H. Zhao, Y. Yang, C. Zhang and H. Yu
Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner byactivating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039003
- DOI:
- 10.4238/gmr.15039003
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Authors: F.L. Campedelli, K.S.F. e Silva, D.A. Rodrigues, J.V.M. Martins, I.R. Costa, M.H. Lagares, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alteratio.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029550
- DOI:
- 10.4238/gmr16029550
Clinical effects and safety review of self-expanding stent surgery for extracranial carotid artery stenosis treatment
Authors: Q.F. Zhu, S.Z. Fang, G.F. Wang, Z.Z. Zhou, S.C. Bian, S.D. Cui, S.B. Yu, F.W. Wang, L.B. Shan and J. Kang
This study aimed to investigate the clinical effects and safety review of self-expanding stent surgery in the treatment of extracranial carotid artery stenosis. Seventy-eight patients with carotid artery stenosis were applied with the self-expanding stent for endovascular interventional therapy. Eighty-one stents were implante.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.5
- DOI:
- 10.4238/2014.July.7.5