Differentially Expressed Genes
Preliminary analysis on the developmental transcriptomes of swallowtail butterfly Papilio polytes (Lepidoptera: Papilioidae)
Authors: Shun Yao, Yun-liang Wang, Rui-song Tao, Cheng-yong Su, Jia-sheng Hao
The butterflies are one of the insect groups which undergo typical complete metamorphosis in their life history. However, up to now, little is known about the genomic mechanism that regulates the butterfly metamorphosis. In this study, using a swallowtail butterfly P. polytes as a model organism, a high-throughput sequencing p.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039902
- DOI:
- 10.4238/gmr16039902
Identification of differentially expressed genes in pathways of cerebral neurotransmission of anovulatory mice
Authors: M.A. Azevedo Jr. and I.D.C.G. Silva
Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocys.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039622
- DOI:
- 10.4238/gmr16039622
Expression profiling analysis of hypoxic pulmonary disease
Authors: L. Zhou, L.M. Wang, H.M. Song, Y.Q. Shen, W.J. Xu, J.H. Xu, Y. Liu, W.W. Yan and J.F. Jiang
Exposure of humans to low levels of environmental oxygen results in alveolar hypoxia and normally causes chronic pulmonary hypertension and morphological alterations of precapillary pulmonary vessels. In this study, the microarray dataset GSE11341 was used to identify potential differentially expressed genes related with human lung microvascular endotheli.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.7.2
- DOI:
- 10.4238/2013.October.7.2
Regulation network analysis of testicular seminoma at various stages of progression
Authors: J.-J. Sha, Y.-H. Dong, D.-M. Liu, J.-J. Bo, Y.-R. Huang, Z. Li and P. Ping
Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testi.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.March.11.11
- DOI:
- 10.4238/2013.March.11.11
Identification of differently expressed genes in leukemia using multiple microarray datasets
Authors: Z.Y. Zhang, R.Q. Xu, T.J. Guo, M. Zhang, D.X. Li and X.Y. Lu
The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto E.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.9
- DOI:
- 10.4238/2014.December.12.9
Digital expression analysis of the genes associated with salinity resistance after overexpression of a stress-responsive small GTP-binding RabG protein in peanut
Authors: J.M. Sui, G. Li, G.X. Chen, M.Y. Yu, S.T. Ding, J.S. Wang and L.X. Qiao
The Rab protein family is the largest family of the small GTP-binding proteins. Among them, the RabG genes are known to be responsive to abiotic stresses, but the molecular mechanisms of the stress responses mediated by RabG genes in plants is poorly understood. To investigate the molecular mechanism of AhRabG gene in peanut, .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019432
- DOI:
- 10.4238/gmr16019432
Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus
Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang
We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.1
- DOI:
- 10.4238/2014.January.3.1
Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma
Authors: J. Liu, X.Y. Yang and W.J. Shi
Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC an.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.8
- DOI:
- 10.4238/2014.January.8.8
Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles
Authors: L. Dong1, K.H. Bi1, N. Huang1 and C.Y. Chen2
Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL sam.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017170
- DOI:
- 10.4238/gmr.15017170
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance
Authors: M. Zhang and S.C. Luo
The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017496
- DOI:
- 10.4238/gmr.15017496