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Cyp2c9

Animal Genetics   Research Article

Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9

Authors: K. Khalighi, G. Cheng, S. Mirabbasi, B. Khalighi, Y. Wu and W. Fan

Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene poly.. Read More»

Genet. Mol. Res. 16(3):
gmr16039737
DOI:
10.4238/gmr16039737
Human Genetics   Research Article

Pharmacogenetics-based warfarin dose prediction algorithm for patients with heart valve replacement in Southeast China

Authors: M.Q. Lin, J. Zhang, H.F. Qiu, X.B. Xie and H.T. Song

This study was designed to analyze the influence of polymorphisms in CYP2C9, VKORC1, CYP4F2, GGCX, and EPHX1 genes on the optimal warfarin dosage in patients who have undergone artificial heart valve replacement and establish an algorithm for use by physicians in Southeast China to predict each patient’s optimal steady-s.. Read More»

Genet. Mol. Res. 16(3):
gmr16038881
DOI:
10.4238/gmr16038881
Cytogenomics   Research Article

Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response

Authors: J.A. Nastasi-Catanese1, J.R. Padilla-Guti�©rrez2, Y. Valle2, F. Ortega-Guti�©rrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6

Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 fa.. Read More»

Genet. Mol. Res. 12(4):
2013.October.10.7
DOI:
10.4238/2013.October.10.7
Human Genetics   Research Article

Effect of CYP2C9*3 mutant variants on meloxicam pharmacokinetics in a healthy Chinese population

Authors: M. Zhang, Y. Yang, G. Zhao, X. Di, L. Xu, N. Jiang, J. Xu and X. Xu

The aim of this study was to investigate the effect of the CYP2C9*3 (CYP2C9 1075 A>C) polymorphism on meloxicam pharmacokinetics in a Chinese population. Twenty-four healthy volunteers were enrolled in this study. The pyrosequencing technique was used to identify polymorphisms of CYP2C9. The concentration of meloxicam in pl.. Read More»

Genet. Mol. Res. 13(1):
2014.February.13.1
DOI:
10.4238/2014.February.13.1
Human Genetics   Research Article

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China

Authors: Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyz.. Read More»

Genet. Mol. Res. 9(3):
vol9-3gmr938
DOI:
10.4238/vol9-3gmr938
Medical Genetics   Research Article

Prevalence of CYP2C9 and VKORC1 alleles in the Argentine population and implications for prescribing dosages of anticoagulants

Authors: P. Scibona, M.A. Redal, L.G. Garfi, J. Arbelbide, P.F. Argibay and W.H. Belloso

Dicumarinic oral anticoagulants have a narrow therapeutic range and a great individual variability in response, which makes calculation of the correct dose difficult and critical. Genetic factors involved in this variability include polymorphisms of genes that encode the metabolic enzyme CYP2C9 and the target enzyme vitamin K .. Read More»

Genet. Mol. Res. 11(1):
http://dx.doi.org/2012.January.9.8
DOI:
http://dx.doi.org/10.4238/2012.January.9.8