Cyp2c19
Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9
Authors: K. Khalighi, G. Cheng, S. Mirabbasi, B. Khalighi, Y. Wu and W. Fan
Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene poly.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039737
- DOI:
- 10.4238/gmr16039737
Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response
Authors: J.A. Nastasi-Catanese1, J.R. Padilla-Guti�©rrez2, Y. Valle2, F. Ortega-Guti�©rrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6
Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 fa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.7
- DOI:
- 10.4238/2013.October.10.7
Influence of CYP2C19 on Helicobacter pylori eradication in Brazilian patients with functional dyspepsia
Authors: D.D. Nabinger, L.E. Mazzoleni, G.B. Sander, F. Mazzoleni, M.C. Os�³rio, M.G. Klein, T.F. Rech, L. Basso da Silva, G.S. de Moraes, R.A. Cristovam, E.F. Nardelli, C.F.M. Francesconi and D. Simon
The aim of this study was to examine the effect of polymorphisms in the cytochrome P450 (CYP) 2C19 gene (CYP2C19) on the Helicobacter pylori eradication rate in Brazilian patients with functional dyspepsia. Adults diagnosed with functional dyspepsia based on the ROME III criteria and infected with H. pylori were recruited to this study. The patients were .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038734
- DOI:
- 10.4238/gmr.15038734
Association of CYP2C19*3 gene polymorphism with breast cancer in Chinese women
Authors: C.Q. Gan, X.Y. Wang, Y.D. Cao, W.X. Ye, H. Liu and Y.Y. Sun
Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese H.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.3
- DOI:
- 10.4238/2011.December.5.3
Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China
Authors: Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su
We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyz.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr938
- DOI:
- 10.4238/vol9-3gmr938