Collagen
Novel and recurrent COL2A1 mutations in Chinese patients with spondyloepiphyseal dysplasia
Authors: L.H. Cao L. Wang C.Y. Ji L.B. Wang H.W. Ma Y. Luo
Spondyloepiphyseal dysplasia (SED) is an autosomal dominant skeletal dysplasia characterized by short stature, abnormal epiphyses and flattened vertebral bodies. SED is mainly caused by mutations in the gene encoding the type II procollagen Ã?±-1 chain (COL2A1). We looked for mutations in COL2A1 in three unrelated Chinese families with SED. Putative mutatio.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.27.1
- DOI:
- 10.4238/2012.September.27.1
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells
Authors: D.Y. Chen and G.F. Su
Chronic inflammation develops in the retinal microvasculature under sustained hyperglycemia and is implicated in the pathogenesis of diabetic retinopathy. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 have been reported to promote pro-inflammatory cytokines, which are involved in the pathogenesis of proliferative diabe.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016920
- DOI:
- 10.4238/gmr.15016920
hBMP-7 induces the differentiation of adipose-derived mesenchymal stem cells into osteoblast-like cells
Authors: Y. Ren, C. Han, J. Wang, Y. Jia, L. Kong, T. Eerdun, L. Wu and D. Jiang
The aim of this study was to investigate the differentiation potential of adipose-derived mesenchymal stem cells (ADMSCs) into osteoblasts by human bone morphogenetic protein-7 (hBMP-7) induction. ADMSCs were isolated from the subcutaneous adipose tissue of a rabbit, and then transfected with the pcDNA3.1 vector alone and pcDNA3.1-hBMP-7 (hBMP-7), respect.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038791
- DOI:
- 10.4238/gmr.15038791
Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats
Authors: Y. Zhou, W.P. Zhu, X.J. Cai and M. Chen
We sought to determine the efficacy of atomized paclitaxel liposome inhalation treatment of pulmonary fibrosis in a bleomycin-induced rat model. Forty male Sprague-Dawley rats were randomly divided into four groups: healthy control, pulmonary fibrosis without treatment, paclitaxel liposome inhalation-treated, and intravenous p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027309
- DOI:
- 10.4238/gmr.15027309
Therapeutic influence of intraperitoneal injection of Wharton�s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis
Authors: H.J. Luo,X.M. Xiao,J. Zhou and W. Wei
To study the effect of Wharton’s jelly-derived mesenchymal stem cells (WJMSCs) on the rat salpingitis model, 50 female Wistar rats were randomly divided into one control and five model groups. Mixed bacteria were injected into the oviducts of model groups. The treated acute and chronic groups received intraperitoneal injections of WJMSCs (1 x 106) o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.10
Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells
Authors: X.F. Ren, Z.Z. Diao,Y.M. Xi,Z.H. Qi,S. Ren,Y.J. Liu,D.L. Yang,X. Zhang and S.L. Yuan
Bone morphogenetic protein-7 (BMP-7) and SOX9 are important transcription factors in chondrogenesis. In this study, we examined the biological function of the adeno-associated virus (AAV)-mediated BMP-7 and SOX9 double gene in vitro co-transfection of nucleus pulposus cells of human degenerative intervertebral disc. Human intervertebral disc nucleus pulpo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.1
Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats
Authors: Y. Wang, G. Huang, B. Mo and C. Wang
The aim of this study was to determine the effect of artesunate on extracellular matrix (ECM) accumulation and the expression of collagen-IV, matrix metalloproteinase (MMP), and tissue inhibitor of matrix metalloproteinase (TIMP) to understand the pharmacological role of artesunate in pulmonary fibrosis. Eighty Sprague-Dawley .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027530
- DOI:
- 10.4238/gmr.15027530