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Human Genetics   Research Article

Molecular Diagnosis of X-Fragile Syndrome: Perspectives for the Public Health System in the Central Region of Brazil

Authors: K.B. Penteado, C.I.S. Gressler, A.D. Da Cruz, T.C. Vieira, & M.A. D. Gigonzac

X-Fragile Syndrome (FXS) is the most common cause of inherited intellectual disability and the second of genetic origin, with an estimated prevalence of 1/4000 men and 1/6000 women. The etiology is associated with a trinucleotide expansion of CGG sequences and hypermethylation of the promoter region of the FMR1 (Fragile-X Ment.. Read More»

Genet. Mol. Res. 16(4):
gmr16039848
DOI:
10.4238/gmr16039848
Plant Genetics   Research Article

In vivo antimutagenic activity of the medicinal plants Pfaffia glomerata (Brazilian ginseng) and Ginkgo biloba

Authors: I.V. Almeida, E. Düsman, G.I. Mattge, F. Toledo, A.F. Reusing and V.E.P. Vicentini

Complementary and alternative therapies, including the use of medicinal plants, have become almost standard among the world’s population. Pfaffia glomerata (PG), popularly known as Brazilian ginseng, is widely used as a restorer of vital functions, increasing mental balance, and is used for the treatment of diabetes and .. Read More»

Genet. Mol. Res. 16(3):
gmr16039785
DOI:
10.4238/gmr16039785
Plant Genetics   Research Article

Chemotherapeutical effects of the herbal medicine Uncaria tomentosa (Willd.) DC.

Authors: I.V. Almeida, L.C. Soares, F.T. Lucio, L.B. Cantagalli, A.F. Reusing and V.E.P. Vicentini

The use of medicinal plants dates back to the beginning of humanity, and today their application as complementary therapy has been widely disseminated as an alternative to conventional therapy. The medicinal plant named Uncaria tomentosa (Willd.) DC. (known as cat’s claw) is a common woody vine of the Amazon forest that .. Read More»

Genet. Mol. Res. 16(3):
gmr16039782
DOI:
10.4238/gmr16039782
Plant Genetics   Review Article

Contributions of classical and molecular cytogenetic in meiotic analysis and pollen viability for plant breeding

Authors: M.P. Lavinscky, M.M. Souza, G.S. Silva and C.A.F. Melo

The analysis of meiotic behavior has been widely used in the study of plants as they provide relevant information about the viability of a species. Meiosis boasts a host of highly conserved events and changes in genes that control these events will give rise to irregularities that can alter the normal course of meiosis and may.. Read More»

Genet. Mol. Res. 16(3):
gmr16039582
DOI:
10.4238/gmr16039582
Plant Genetics   Research Article

Chromosome variations and diversity of Epidendrum ibaguense Lindl. (Orchidaceae) on the Tepequém’s Tepuy, Roraima, Brazil

Authors: S.R. Nóbrega, A.L.F. Coelho, C.F. Verola, I.R. Costa, R. Vilaça, F.J.F. Luz and W.F. Araújo

Studies addressing chromosome variations have elucidated many points regarding the taxonomy of the Orchidaceae. Epidendrum L. besides being one the largest orchid genera, present remarkable morphological, and inter- and intraspecific chromosome variations. Thus, based on a previous report on flower color variation in individua.. Read More»

Genet. Mol. Res. 16(3):
gmr16039754
DOI:
10.4238/gmr16039754
Plant Genetics   Research Article

Intraspecific and interspecific polyploidy of Brazilian species of the genus Inga (Leguminosae: Mimosoideae)

Authors: M.F. Figueiredo, R.L.A. Bruno, A.E. Barros e Silva, S. Nascimento, I.G. Oliveira and L.P. Felix

We investigated the karyotypes of 13 species of six sections of the genus Inga (Leguminosae-Mimosoideae) from Brazil. We used conventional Giemsa staining to identify numerical chromosomal variations and looked for karyotypic evolutionary patterns. The karyotypes generally had small chromosomes, varying from metacentric to sub.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.April.29.18
DOI:
http://dx.doi.org/10.4238/2014.April.29.18
Human Genetics   Research Article

Y-STR haplotype diversity and population data for Central Brazil: implications for environmental forensics and paternity testing

Authors: T.C. Vieira, M.A.D. Gigonzac, D.M. Silva, R.G. Rodovalho, G.S. Santos and A.D. da Cruz

The central region of Brazil was colonized by internal migration of individuals of different origins, who contributed to the genetic diversity existing in this population. This study determined the allele frequencies and haplotype diversity of Y-STRs in Goiás State, Central Brazil, and compared the data obtained with a .. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.April.30.1
DOI:
http://dx.doi.org/10.4238/2014.April.30.1
Human Genetics   Research Article

Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter’s syndrome

Authors: H.-G. Zhang, Z.-B. Zhang, R.-X. Wang, Y. Yu, X.-W. Yu, E. Fadlalla and R.-Z. Liu

The prevalence of microdeletions of azoospermia factor (AZF) among azoospermic Klinefelter’s syndrome (KFS) patients shows conflicting data. We aimed to detect this frequency in a Northeast Chinese population, and to investigate the possible association between AZF microdeletions and KFS by comparison with previous conflicting reports. Eighty men af.. Read More»

Genet. Mol. Res. 12(4):
2013.October.24.9
DOI:
10.4238/2013.October.24.9
Human Genetics   Research Article

Analysis of BCR/ABL transcripts in healthy individuals

Authors: J.A. Boquett1, J.R.P. Alves2 and C.E.C. de Oliveira3

The chimeric oncogene BCR/ABL, which is the product of reciprocal translocation between chromosomes 9 and 22, is a known molecular marker of chronic myeloid leukemia (CML), and is related to the major factors involved in leukemogenesis. Some previous studies have also reported the presence of this oncogene in peripheral blood cells of healthy individuals... Read More»

Genet. Mol. Res. 12(4):
2013.October.24.8
DOI:
10.4238/2013.October.24.8
Plant Genetics   Research Article

Different timing and spatial separation of parental chromosomes in intergeneric somatic hybrids between Brassica napus and Orychophragmus violaceus

Authors: L. Ding, Z.G. Zhao, X.H. Ge and Z.Y. Li

Experimental and newly formed hybrids and polyploids generated by wide crosses usually show varying degrees of cytological instability. The spatial separation of parental genomes and uniparental chromosome elimination in hybrid cells has been reported in many hybrids from plants and animals. Herein, the behavior of parental ge.. Read More»

Genet. Mol. Res. 13(2):
2014.April.8.3
DOI:
10.4238/2014.April.8.3

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