Ankylosing Spondylitis
CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population
Authors: J. Zepa, L. Silami�·ele, I. Bulina, V. Lavrentjevs, I. Trapina, J. Klovins, D. Andersone, A. Lejnieks and L. Nikitina-Zake
Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunityrelated genes have pleiotropic effects. Multiple functional polymorphisms .. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18081
- DOI:
- http://dx.doi.org/10.4238/gmr18081
Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis
Authors: J.T. Wen, D.H. Zhang, P.F. Fang, M.H. Li, R.J. Wang, S.H. Li
Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated level.. Read More»
- Genet. Mol. Res. 16(1):
- Ankylosing spondylitis; Th1; Th2; Inflammatory cytokines
- DOI:
- Ankylosing spondylitis; Th1; Th2; Inflammatory cytokines
Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
Tumor necrosis factor receptor-II nt587 polymorphism in Chinese Han patients with ankylosing spondylitis
Authors: X. Li, M. Wang, R. Ma, T. Zhang, J. Liu, J.W. Chen and W. Peng
We aimed to explore the association between the onset of ankylosing spondylitis (AS) and nt587 polymorphisms of the tumor necrosis factor receptor II (TNFRII) gene in the Han population of Hunan Province, China. Correlation analysis was performed in a case-control study involving 100 AS cases and 100 healthy controls. The nt58.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.12
- DOI:
- 10.4238/2014.July.7.12
Meta-analysis of differentially expressed genes in ankylosing spondylitis
Authors: Y.H. Lee and G.G. Song
The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a metaanalysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.6
- DOI:
- 10.4238/2015.May.18.6
TNFR1 -383 AÃ?Â?C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study
Authors: V. Mordovskii, A. Semenchukov, S.Y. Nikulina, A.B. Salmina, A. Chernova, E. Kapustina, A. Kents, A. Ohapkina, E. Moskaleva, P.E. Maltese, P. Convertini, M. Bertelli
The aim of this study was to assess the association between the TNFR1 rs2234649 polymorphism and ankylosing spondylitis susceptibility in a Russian Caucasian population. A total of 41 ankylosing spondylitis patients and 43 healthy controls, matched according to age and sex, were enrolled, and polymerase chain reac.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019581
- DOI:
- 10.4238/gmr16019581
Association between IL-4 gene polymorphisms, IL-4 serum levels, and ankylosing spondylitis
Authors: X.L. Liu, J.K. Ren and Y.L. Su
We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the c.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048898
- DOI:
- 10.4238/gmr15048898
Expression of TNF-�±, VEGF, and MMP-3 mRNAs in synovial tissues and their roles in fibroblast-mediated osteogenesis in ankylosing spondylitis
Authors: K.G. Liu, Q.H. He, J.W. Tan and G.J. Liao
The aim of this study was to explore the mRNA levels of tumor necrosis factor-α (TNF-α), vessel endothelial growth factor (VEGF), and matrix metalloproteinase-3 (MMP-3) in synovial tissues in ankylosing spondylitis (AS), and to analyze the functions of these proteins in the differentiation of AS synovial tissue fibroblasts into osteoblasts (OB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.28
- DOI:
- 10.4238/2015.June.18.28
Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis
Authors: J.W. Gao, K.F. Zhang, J.S. Lu and T. Su
Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.7
- DOI:
- 10.4238/2015.December.16.7
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
Authors: G.X. Jin, J.Z. Duan, W.L. Guo, L. Li, S.Q. Cui and H. Wang
We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlin.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.3
- DOI:
- 10.4238/2013.May.21.3