Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis
Authors: J.W. Gao, K.F. Zhang, J.S. Lu and T. Su
Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.7
- DOI:
- 10.4238/2015.December.16.7
Antimutagenic and anticarcinogenic effects of wheat bran in vivo
Authors: J.R. Pesarini, P.T. Zaninetti, M.O. Mauro, C.M. Carreira, J.B. Dichi, L.R. Ribeiro, M.S. Mantovani and R.J. Oliveira
Previous studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.5
- DOI:
- 10.4238/2013.May.14.5
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
Expression of Magnaporthe oryzae genes encoding cysteine-rich proteins secreted during nitrogen starvation and interaction with its host, Oryza sativa
Authors: J. Yang, M.L. Liang, J.L. Yan, Y.Q. Yang, L. Liu, C. Liu, L.J. Yang and C.Y. Li
Previous studies have shown that the blast fungus, Magnaporthe oryzae, may experience nitrogen starvation during infection of its plant host (rice,Oryza sativa). Here, we studied the expression of seven genes encoding cysteine-rich proteins with N-terminal signal peptides during nitrogen limitation and throughout the infection process. Some genes were upr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.10
- DOI:
- 10.4238/2015.December.16.10
KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population
Authors: Q.D. Li, F.J. Li, X.C. Liu and H. Jiang
Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension. The current study aimed to confirm the association between the polymorphism in KLK1 and coronary artery stenosis (CAS). A total of 458 patients with CAS and 482 controls were used in a case-control study carr.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.4
- DOI:
- 10.4238/2013.May.14.4
Overexpression of pucC improves the heterologous protein expression level in a Rhodobacter sphaeroides expression system
Authors: L. Cheng,G. Chen,G. Ding,Z. Zhao,T. Dong and Z. Hu
The Rhodobacter sphaeroides system has been used to express membrane proteins. However, its low yield has substantially limited its application. In order to promote the protein expression capability of this system, the pucC gene, which plays a crucial role in assembling the R. sphaeroides light-harvesting 2 complex (LH2), was overexpressed. To build a puc.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.21
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.21
In vitro effect of dexmedetomidine on the respiratory burst of neutrophils
Authors: S.L. Chen, W. Zhou, F.Z. Hua, Y. Chen, X.L. Zheng, X.F. Long and J. Lu
The immunosuppressive effects of dexmedetomidine, a highly selective and widely used a2-adrenoceptor agonist for sedation, analgesia, and stress management, are investigated in vitro. In the present study, the respiratory burst of human neutrophils separated from venous blood was evaluated with dexmedetomidine treatment after .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028069
- DOI:
- 10.4238/gmr.15028069
Development and characterization of microsatellite loci for genetic studies of the sugarcane borer, Diatraea saccharalis (Lepidoptera: Crambidae)
Authors: V.A.C. Pavinato, K.L. Silva-Brand�£o, M. Monteiro, M.I. Zucchi, J.B. Pinheiro, F.L.F. Dias and C. Omoto
We present polymorphic microsatellite markers isolated for genetic studies of the sugarcane borer, Diatraea saccharalis (Fabricius). We isolated 16 microsatellite loci through an enriched genomic library protocol. After characterization, 12 markers showed polymorphic information expressed in the observed number of alleles (ranging from 2 to 7; 5 on averag.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.3
- DOI:
- 10.4238/2013.May.14.3
Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population
Authors: L.J. Wang, H.T. Wang and X.X. Wang
We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028080
- DOI:
- 10.4238/gmr.15028080
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2