Screening for mutations in RPGR and RP2 genes in Jordanian families with X-linked retinitis pigmentosa
Authors: M.F. Haddad, O.F. Khabour, K.A.Y. Abuzaideh and W. Shihadeh
Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous disease causing progressive degeneration of retinal photoreceptor cells. X-linked RP (XLRP), in which photoreceptor degeneration begins in early childhood and complete blindness often occurs by the fourth decade of life, constitutes the most severe form of.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027842
- DOI:
- 10.4238/gmr.15027842
Rapid discrimination between four seagrass species using hybrid analysis
Authors: M. Osathanunkul,P. Madesis,S. Ounjai,C. Suwannapoom and A. Jampeetong
Biological species are traditionally identified based on their morphological features and the correct identification of species is critical in biological studies. However, some plant types, such as seagrass, are taxonomically problematic and difficult to identify. Furthermore, closely related seagrass species, such as Halophila spp, form a taxonomically u.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.10
Genetic structure of Pilosocereus gounellei (Cactaceae) as revealed by AFLP marker to guide proposals for improvement and restoration of degraded areas in Caatinga biome
Authors: E.R. Monteiro, D.K. Strioto, A.C.S. Meirelles, C.A. Mangolin and M.F.P.S. Machado
Amplified fragment length polymorphism (AFLP) analysis was used to evaluate DNA polymorphism in Pilosocereus gounellei with the aim of differentiating samples grown in different Brazilian semiarid regions. Seven primer pairs were used to amplify 703 AFLP markers, of which 700 (99.21%) markers were polymorphic. The percentage of polymorphic markers ranged .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.2
- DOI:
- 10.4238/2015.December.15.2
Association of KCNJ11 with impaired glucose regulation in essential hypertension
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1127
- DOI:
- 10.4238/vol10-2gmr1127
Deep sequencing-based analysis of gene expression in bovine mammary epithelial cells after Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae infection
Authors: L. Xiu, Y.B. Fu, Y. Deng, X.J. Shi, Z.Y. Bian, A. Ruhan and X. Wang
The goal of this study was to characterize the transcriptome of primary bovine mammalian epithelial cells (pBMECs) and to identify candidate genes for response and resistance to Staphylococcus aureus (strain S108), Escherichia coli (strain E23), and Klebsiella pneumoniae (strain K96) infection. Using Solexa sequencing, approximately 4.9 million total sequ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.1
- DOI:
- 10.4238/2015.December.15.1
miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4
Authors: Y.H. Zhang, Q.Q. Wang, H. Li, T. Ye, F. Gao and Y.C. Liu
Radiotherapy is one of the most important treatments for esophageal cancer, but radioresistance remains a major challenge. Previous studies have shown that microRNAs (miRNAs or miRs) are involved in human cancers. miR-124 has been widely reported in various cancers and it is intimately involved in proliferation, cell cycle reg.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027893
- DOI:
- 10.4238/gmr.15027893
Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis
Authors: A.E. Osman, M. Mubasher, N.E. ElSheikh, H. AlHarthi, I.A. AlAlallah, A.A. Elbeshir, M. Abashar, N. Elsidig, G. ElGhazali and A.-S.A. Fadil
Osteomyelitis is a progressive bone infection disease caused by destructive immunological inflammatory reactions following new bone formation. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the pro-inflammatory cytokine response. In this study, we investigated 9 single nucleotide polymorphisms in 5 different cytokine/c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.4
- DOI:
- 10.4238/2015.December.15.4
Cytoplasmic polymorphism and evolutionary history of plum cultivars: Insights from chloroplast DNA sequence variation of trnL-trnF spacer and aggregated trnL intron & trnL-trnF spacer
Authors: S.B. Mustapha,H. Ben Tamarzizt,G. Baraket,D. Abdallah and A. Salhi-Hannachi
We screened for polymorphisms of the non-coding region of plastid DNA in plum trees. Sequencing data from the trnL-trnF chloroplast region were used to reveal a pattern of diversity, establish phylogenetic relationships, and test the selection pressure or evolutionary demography scenario for plastome DNA. The size of the non-coding regions varied from 398.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.11
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of se.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1125
- DOI:
- 10.4238/vol10-2gmr1125
Effects of lentiviral short hairpin RNA silencing of Toll-like receptor 4 on the lens epithelial cell line HLEC
Authors: H.T. Yu and P.R. Lu
The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 (TLR4) gene silencing. HLEC cells were transfected with four TLR4-short hairpin RNA (shRNA) lentiviral vectors or the control lentivirus (pGCL-GFP-shRP-1, -2, -3, -4, NC). TL.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027897
- DOI:
- 10.4238/gmr.15027897