Relationship between TBX20 gene polymorphism and congenital heart disease
Authors: X.F. Yang, Y.F. Zhang, C.F. Zhao, M.M. Liu, J.P. Si, Y.F. Fang,W.W. Xing and F.L. Wang
Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027374
- DOI:
- 10.4238/gmr.15027374
Mutation profile of KRAS and BRAF genes in patients with colorectal cancer: association with morphological and prognostic criteria
Authors: M. Samara, K. Kapatou, M. Ioannou, Ã?Â?. Kostopoulou, R. Papamichali, C. Papandreou, A. Athanasiadis and G. Koukoulis
KRAS and BRAF mutations are well-recognized molecular alterations during colorectal carcinogenesis, but there is little agreement on their effect on tumor characteristics. Therefore, we aimed to evaluate the distribution of the most common KRAS and BRAF mutations in Greek patients with colorectal cancer and their possible associations with clinical histop.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.6
- DOI:
- 10.4238/2015.December.14.6
Gene expression and enzyme activity of lipoprotein lipase correlate with intramuscular fat content in Guangxi san-huang and Arbor Acres chickens
Authors: Y.N. Huang, J. Wang, B.J. Chen, Q.Y. Jiang, Y.F. Guo, G.Q. Lan and H.S. Jiang
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. This study investigated LPL gene expression, LPL enzyme activity, and the correlation of each with intramuscular fat (IMF) in Chinese Guangxi san-huang (GXSH) and Arbor Acres (AA) chickens. The results showed that age and breed had significant effects on LPL express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027414
- DOI:
- 10.4238/gmr.15027414
Translation of foot-and-mouth disease virus RNA: factors influencing alternative AUG selection
Authors: J.L. Liu, Y.H. Ma, J.Y. Xu, Y.X. Chen, S.E. Chen and Z.R. Ma
The mechanism of alternative AUG usage in foot-and-mouth disease virus is not completely understood. Using simple computational approaches, we evaluated the contributions of overall codon bias, quantitative codon bias, and %GC of the region between the two alternative AUGs, Region-La, as well as the nucleotide bias of the sequence context flanking each AU.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.7
- DOI:
- 10.4238/2015.December.14.7
Molecular phylogeny of Lathyrus species: insights from sequence-related amplified polymorphism markers
Authors: S. Marghali, A. Touati, M. Gharbi, D. Sdouga and N. Trifi-Farah
Sequence-related amplified polymorphism (SRAP) markers were used to evaluate the intra- and interspecific variation among 40 Lathyrus genotypes (four species) (Fabaceae). Ten SRAP primer combinations resulted in a total of 94 bands, and they exhibited high interspecific variability. The genetic differentiation among Lathyrus, estimated using AMOVA, was hi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017198
- DOI:
- 10.4238/gmr.15017198
Expression and prognostic influence of NF-�ºB and EGFR in esophageal cancer
Authors: Y.Q. Zhang, J.J. Zhang , H.J. Song and D.W. Li
The goal of this study was to investigate the expression profiles of nuclear factor-kappa B (NF-κB) and epidermal growth factor receptor (EGFR) in esophageal cancer and to determine their association with tumor prognosis. This study included 40 esophageal cancer patients [22 men and 18 women; average age = 62.7 ± 3.9 years; tumor-node-metasta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.9
- DOI:
- 10.4238/2015.December.14.9
Genetic variation in Rhodomyrtus tomentosa (Kemunting) populations from Malaysia as revealed by inter-simple sequence repeat markers
Authors: T.S. Hue, T.L. Abdullah, N.A.P. Abdullah and U.R. Sinniah
Kemunting (Rhodomyrtus tomentosa) from the Myrtaceae family, is native to Malaysia. It is widely used in traditional medicine to treat various illnesses and possesses significant antibacterial properties. In addition, it has great potential as ornamental in landscape design. Genetic variability studies are important for the rational management and conserv.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.10
- DOI:
- 10.4238/2015.December.14.10
Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility
Authors: X.H. Liu, C.G. Xie, Y. An, X.X. Zhang and W.B. Wu
Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.12
- DOI:
- 10.4238/2015.December.14.12
miR-218 tissue expression level is associated with aggressive progression of gastric cancer
Authors: X.X. Wang, S.J. Ge, X.L. Wang, L.X. Jiang, M.F. Sheng and J.J. Ma
The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reacti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027521
- DOI:
- 10.4238/gmr.15027521
Expression of TRPM8 in diabetic rats and its relationship with visceral pain stimulation
Authors: J. Liu, S.L. Dong, N. Li, B.S. Ouyang and F. Qi
Transient receptor potential cation channel, subfamily M, member 8 (TRPM8) is a nonselective cation channel and a candidate for cold sensation signaling, but the relationship between TRPM8 and diabetes remains unclear. In the present study, we determined the expression levels of TRPM8 messenger RNA (mRNA) and the levels of the TRPM8 protein in the bladder.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017219
- DOI:
- 10.4238/gmr.15017219