S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer
Authors: Z. Hussain, M.I. Khan, M. Shahid and F.N. Almajhdi
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloprotein.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.6
- DOI:
- 10.4238/2013.April.10.6
Analysis of uridine diphosphate glucuronosyl transferase 1A1 gene mutations in neonates with unconjugated hyperbilirubinemia
Authors: X.H. Guo, Y.F. Sun, M. Cui1, J.B. Wang, S.Z. Han and J. Miao
This study was carried out to analyze uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) gene mutations in neonates with unconjugated hyperbilirubinemia, from two different ethnic groups. Polymerase chain reaction and gene sequencing were used to analyze the differences in genotypes and allele frequencies of differ.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028373
- DOI:
- 10.4238/gmr.15028373
Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population
Authors: F.M. Feng, X.X. Liu, Y.H. Sun, P. Zhang, S.F. Sun, B. Zhang, X.T. Wang and L.J. Lu
We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using pol.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.14
- DOI:
- 10.4238/2014.September.26.14
Regulating effects of insertion direction of matrix attachment regions on transgenic expression in stably transformed Chinese hamster ovary cells
Authors: F. Wang, J.H. Zhang, T.Y. Wang, W.H. Dong, X.J. Yang, X.Y. Wang,L. Wang, R. Yang, Q. Li and C.P. Zhao
We investigated the effects of different directions of insertion of matrix attachment region (MAR) sequences on transgenic expression in stably transformed Chinese hamster ovary (CHO) cells. The MAR sequences were inserted in forward or reverse directions into the expression vectors, and transfected into CHO cells. The expression of the chloramphenicol ac.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.12
- DOI:
- 10.4238/2015.June.26.12
Comparative analysis of the liver tissue transcriptomes of Mongolian and Lanzhou fat-tailed sheep
Authors: X. Cheng, S.G. Zhao, Y. Yue, Z. Liu, H.W. Li and J.P. Wu
Research on gene regulation has been made possible with the help of RNA sequencing applications such as RNA-Seq technology for high-throughput sequencing platforms. Recent studies have explored the transcriptomes from different tissues of domestic animals using RNA-Seq technology, but little research has been done to study the.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028572
- DOI:
- 10.4238/gmr.15028572
Value of diffusion weighted imaging in the differential diagnosis of benign and malignant breast lesions at 3.0T MRI
Authors: X.Y. Jiang, Q.Z. Xie, X.S. Cao, T. Gao, C.Y. Xing and X.L. Li
The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent br.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.15
- DOI:
- 10.4238/2014.September.26.15
Expression and diagnostic value of proteins in Mycobacterium tuberculosis
Authors: Z.Y. Zhu, Y. Liu, H.B. Wang, J.Z. Xiao, Y.F. Qiu, L. Yan, D. Chen, A.G. Liu and X. Yang
We constructed a prokaryotic expression vector expressing the Mycobacterium tuberculosis protein TB16.3, as well as 3 other proteins, including TB15.3, CFP-10, and Rv2626C, which were purified and analyzed for their effectiveness as detection antibodies. The TB16.3 genes of M. tuberculosis H37Rv geno.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.16
- DOI:
- 10.4238/2014.September.26.16
Genomic analysis of gum disease and hypertrichosis in foxes
Authors: J.-A.B.J. Clark, D. Whalen and H.D. Marshall
Since the 1940s, a proliferative gingival disease called hereditary hyperplastic gingivitis (HHG) has been described in the farmed silver fox, Vulpes vulpes (Dyrendahl and Henricson 1960). HHG displays an autosomal recessive transmission and has a pleiotropic relationship with superior fur quality in terms of length and thickn.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025363
- DOI:
- 10.4238/gmr.15025363
Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in patients with decompensated liver cirrhosis
Authors: C.H. Guo, L.X. Han, M.R. Wan, G.J. Deng and J.H. Gan
We explored the immunomodulatory effects of bone marrow mesenchymal stem cells (BMSCs) on peripheral blood T lymphocytes in patients with decompensation stage, hepatitis B-associated cirrhosis. MSCs from nine patients were analyzed by flow cytometry. Peripheral blood lymphocytes were isolated for fluorescent staining. Following stimulation by phytohemaggl.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.13
- DOI:
- 10.4238/2015.June.26.13
Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis
Authors: C. Ma, Q.L. Zhou, Y.J. Deng, X. Liang, D.P. Wu and Y.Z. Dong
The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a meta-analysis of published stud.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.17
- DOI:
- 10.4238/2014.September.26.17