Expression profile analysis reveals putative prostate cancer-related microRNAs
Authors: H. Song1*, Y. Liu2*, J. Pan3 and S.T. Zhao1
Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abn.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.4
- DOI:
- 10.4238/2013.October.24.4
Novel association analysis between HLA-DQB1 polymorphisms and rectal cancer based on a cross-validation design
Authors: F.Z. Tong, W.J. Yu, H. Liu
A new study design based on cross-validation of the age at the onset of rectal cancer and the differences between the frequency distributions of relevant genes in 2 groups was developed for identification of disease-related HLA. Patients with rectal cancer were recruited and their age at the time of the first surgery was recor.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.5
- DOI:
- 10.4238/2013.November.26.5
BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males
Authors: K. Suriyaprom1, R. Tungtrongchitr2, K. Thawnashom1 and Y. Pimainog1
Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and ex.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.3
- DOI:
- 10.4238/2013.October.24.3
Genetic diversity of locally adapted sheep from Pantanal region of Mato Grosso do Sul
Authors: B.A. Crispim1, A.B. Grisolia1, L.O. Seno2, A.A. Egito3, F.M. Vargas Junior2 and M.R. Souza2
Sheep of the Pantaneiro breed and seven other breeds, raised in the State of Mato Grosso do Sul, Brazil, were genotyped using eight microsatellite loci. The aim of the present study was to determine the genetic variability, phylogenetic relationship, and patterns of gene introgression and miscegenation among the animals surveyed, to obtain information abo.. Read More»
- Genet. Mol. Res. 12(4):
Relationship between dilated cardiomyopathy and the E23K and I337V polymorphisms in the Kir6.2 subunit of the KATP channel
Authors: H.L. Xi1*, J.F. Liu1*, L. Li2 and J. Wan1
ATP-sensitive potassium channels play an important role in myocardial electrical activity. Genetic disruption of these channels predisposes the myocardium to cardiac diseases. Herein we investigated whether two polymorphisms, E23K and I337V, located in the Kir6.2 subunit of ATP-sensitive potassium channels are associated with dilated cardiomyopathy (DCM) .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.4
- DOI:
- 10.4238/2013.October.10.4
Effects of destrin pathway mutations on the gene expression profile
Authors: J.N. Xu, X. Liu, H. Wang, C.M. Hu, Q.H. Luo and Q.Q. Zhou
This study aimed to explore the interaction and crosstalk between pathways in response to destrin mutations. All the pathways from the MINT database were downloaded, a protein-protein interaction network was then constructed, and the crosstalk between pathways was investigated, in particular, the overlap of 2 significant pathw.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.5
- DOI:
- 10.4238/2014.April.8.5
Identification of orchardgrass (Dactylis glomerata L.) cultivars by using simple sequence repeat markers
Authors: L.-F. Jiang1, X.-Q. Zhang1, X. Ma1, L.-K. Huang1, W.-G. Xie2, Y.-M. Ma1 and Y.-F. Zhao1
The accurate identification of orchardgrass (Dactylis glomerata L.) cultivars is necessary to ensure purity for consumers, the effective utilization of cultivars, and to protect the intellectual property for breeders. Therefore, this study aimed to use SSR to construct DNA fingerprinting of orchardgrass cultivars. The genetic diversity of 32 orchardgrass .. Read More»
- Genet. Mol. Res. 12(4):
Relationship between the acylation-stimulating protein gene and coronary heart disease in the Xinjiang Uygur and Han populations of China
Authors: Y. Chen, Y.T. Ma, S.J. Yang, Y.N. Yang, Z.Y. Fu, X. Xie, X.M. Li and Y.Y. Zheng
The association of the single nucleotide polymorphism 301T>C in the coding region of the acylation-stimulating protein (ASP) gene with coronary heart disease (CHD) was investigated in the Uygur (385 CHD patients and 483 control subjects) and Han (390 CHD patients and 439 control subjects) populations of China. The frequency.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.6
- DOI:
- 10.4238/2014.April.8.6
Mendelian inheritance, genetic linkage, and genotypic disequilibrium at nine microsatellite loci of Cariniana legalis (Mart.) O. Kuntze
Authors: E.V. Tambarussi1, R. Vencovsky1, M.L.M. Freitas2 and A.M. Sebbenn3
Cariniana legalis is one of the largest tropical trees with a wide distribution in the Brazilian Atlantic rainforest. We investigated the Mendelian inheritance, genetic linkage, and genotypic disequilibrium at seven microsatellite loci specifically isolated for C. legalis, and at two previously developed heterologous microsatellite loci. Forty to 100 open.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.11.6
- DOI:
- 10.4238/2013.November.11.6
Changes of gene expression profiles across different phases of vascular calcification in rats
Authors: Z.M. Jiang, X.J. Wu, Y. Liu, X.H. Du, S.J. Shen, L.Y. Xu,W.X. Sun
This study investigated the alteration of gene expression profiles in order to gain a deeper understanding into the molecular mechanism involved in different processes of vascular calcification (VC). Sprague Dawley (SD) rats were injected with 300,000 μg/kg vitamin D3 and gavaged with 25 mg/kg nicotine for 8 or 16 weeks to .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.4
- DOI:
- 10.4238/2013.November.26.4