MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer
Authors: H.C. Zhuo, Y.F. Song, J. Ye, G.X. Lai and D.L. Liu
MicroRNA-154 (miR-154) is dysregulated in some human malignancies and is correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Therefore, we explored the effects of miR-154 on NSCLC tumorigenesis and development. Using quantitative reverse transcription-po.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028173
- DOI:
- 10.4238/gmr.15028173
Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophil migration and reducing interferon-gamma expression
Authors: G. Zhang, K.F. Zhou and Z.H. Lu
The aim of this study was to observe the effect of interleukin (IL)-17 on early immune response and inflammation in the lungs of respiratory syncytial virus (RSV)-infected mice. Specific pathogen-free BALB/c mice were randomly assigned to control, RSV-infected, RSV-infected with phosphate-buffered saline, and RSV-infected + IL-17 intervention groups. The .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017002
- DOI:
- 10.4238/gmr.15017002
Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation
Authors: A.M. Carvajal, P. Huircan, J.M. Dezamour, I. Subiabre1, B. Kerr, R. Morales and E.M. Ungerfeld
Milk fat composition is important to consumer health. During the last decade, some fatty acids (FA) have received attention because of their functional and beneficial effects on human health. The milk FA profile is affected by both diet and genetics. Differences in milk fat composition are based on biochemical pathways, and ca.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027057
- DOI:
- 10.4238/gmr.15027057
Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma
Authors: Y.M. Liu, X.M. Zhai and Y.W. Wu
The purpose of this study was to investigate the association between cellular 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake and the expression of several subtypes of glucose transporters (GLUT) and Ki-67 in diffuse large B-cell lymphoma (DLBCL) and natural killer (NK)/T-cell lymphoma (NKTCL). Cell lines were histologically.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027242
- DOI:
- 10.4238/gmr.15027242
Branches of the NF-�ºB signaling pathway regulate proliferation of oval cells in rat liver regeneration
Authors: W.M. Zhao, Y.L. Qin, Z.P. Niu, C.F. Chang, J. Yang, M.H. Li, Y. Zhou and C.S. Xu1,
The NF-kB (nuclear factor kB) pathway is involved in the proliferation of many cell types. To explore the mechanism of the NF-kB signaling pathway underlying the oval cell proliferation during rat liver regeneration, the Rat Genome 230 2.0 Array was used to detect expression changes of NF-kB signaling pathway-related genes in .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017750
- DOI:
- 10.4238/gmr.15017750
Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson�s disease
Authors: X. Wang, H.A. Yang, X.N. Wang and Y.F. Du
The most significant pathological feature of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027406
- DOI:
- 10.4238/gmr.15027406
Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population
Authors: D.H. Ma, Q.Y. Xu, Y. Liu, Q.Q. Zhai and M.H. Guo
In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polyme.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027570
- DOI:
- 10.4238/gmr.15027570
Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus
Authors: J.S. Gomes, L.B. Minasi, A.D. da Cruz and F.M. Rodrigues
Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the assoc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027672
- DOI:
- 10.4238/gmr.15027672
Role of IL-10 gene polymorphisms in the development of acute pancreatitis
Authors: B.Z. Jiang, L. Tang, H. Xue and D.P. Liu
Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese indivi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027743
- DOI:
- 10.4238/gmr.15027743
Molecular docking of the anticancer bioactive compound proceraside with macromolecules involved in the cell cycle and DNA replication
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, M. AbulFarah, F. Al-Hemaid, F.M. Abou-Tarboush, K.M. Al-Anazi, F.S.M. Al-Anazi and J. Lee
The bioactive compounds proceraside A, frugoside and calotropin, which were extracted from the root bark of Calotropis procera (Aiton) W.T. Aiton (family Asclepiadaceae), were recently reported to inhibit the growth of inhibition against various human cancer cell lines in vitro. However, their modes of action have not been cle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027829
- DOI:
- 10.4238/gmr.15027829