Osteoprotegerin polymorphisms in Chinese Han patients with rheumatoid arthritis
Authors: X.H. Ye, J.L. Chen and R.P. Liu
In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.11
- DOI:
- 10.4238/2015.June.12.11
Association of miR-21 with esophageal cancer prognosis: a meta-analysis
Authors: S.-W. Wen, Y.-F. Zhang, Y. Li, Z.-X. Liu, H.-L. Lv, Z.-H. Li, Y.-Z. Xu, Y.-G. Zhu and Z.-Q. Tian
The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.12
- DOI:
- 10.4238/2015.June.12.12
Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause
Authors: R.L. Dai,Y. Hou,F.B. Li, J.M. Yue,Q. Xi and R.Z. Liu
The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated wi.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.13
- DOI:
- 10.4238/2015.June.12.13
Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo
Authors: H. Wu, K. Wang, W. Liu and Q. Hao
Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-revers.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.1
- DOI:
- 10.4238/2015.June.18.1
NDC80 promotes proliferation and metastasis of colon cancer cells
Authors: X.K. Xing, H.Y. Wu, H.L. Chen and H.G. Feng
Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods. Western .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028312
- DOI:
- 10.4238/gmr.15028312
Mapping and validation of Xanthomonas citri subsp citri genes regulated by putative plant-inducible promoter box (PIP-box)
Authors: F.M.S. Carvalho, J.C.F. Oliveira, M.L. Laia, T.R. Jacob,R.M. Ferreira, M.I.T. Ferro, R.I.D. Tezza, S.M. Zingaretti, C.F. Silva and J.A. Ferro
Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), is a major disease affecting citriculture worldwide, because of the susceptibility of the host and the lack of efficient control methods. Previous studies have reported that some genes of phytopathogenic bacteria possess a consensus nucle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028428
- DOI:
- 10.4238/gmr.15028428
Diversity and genetic parameter estimates for yield and its components in Jatropha curcas L.
Authors: R.G. Freitas, L.A.S. Dias, P.M.R. Cardoso, A.B. Evaristo, M.F. Silva and N.M. Ara�ºjo
Jatropha curcas L. is one of the most promising oilseeds for biodiesel and biokerosene production, but few basic studies or breeding programs have been conducted for the species. We estimated genetic parameters and diversity based on 10 yield traits in 77 half-sib progenies of J. curcas after 52 months in the field, and evaluated correlations between them.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017540
- DOI:
- 10.4238/gmr.15017540
Ancient DNA in historical parchments - identifying a procedure for extraction and amplification of genetic material
Authors: T. Lech
Historical parchments in the form of documents, manuscripts, books, or letters, make up a large portion of cultural heritage collections. Their priceless historical value is associated with not only their content, but also the information hidden in the DNA deposited on them. Analyses of ancient DNA (aDNA) retrieved from parchm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028661
- DOI:
- 10.4238/gmr.15028661
Roles of oxidative DNA damage of bone marrow hematopoietic cells in steroid-induced avascular necrosis of femoral head
Authors: Z.Q. Zhao, R. Bai, W.L. Liu, W. Feng, A.Q. Zhao, Y. Wang, W.X. Wang, L. Sun, L.S. Wu and S.X. Cui
An animal model of steroid-induced avascular necrosis of femoral head (SANFH) was established to investigate the role of oxidative DNA damage of bone marrow hematopoietic cells in SANFH. Forty-five-month-old Japanese white rabbits (male or female, 2.5 ± 0.5 kg) were randomly divided into groups A (methylprednisolone + E.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017706
- DOI:
- 10.4238/gmr.15017706
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development
Authors: T. Zara-Lopes, A.P.A. Gimenez-Martins, C.H.V. Nascimento-Filho, M.M.U. Castanhole-Nunes, A.L.S. Galbiatti-Dias, J.A. Padovani-J�ºnior, J.V. Maniglia, J.L.E. Francisco, E.C. Pavarino and E.M. Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MT.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028222
- DOI:
- 10.4238/gmr.15028222