IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil
Authors: I.A. Pess�´a, F.E.S. Sagica, N.P. Anselmo, J.R.N. Brito an E.H.C. de Oliveira
Glioma is a term used to describe tumors derived from glial cells. These tumors are divided into subgroups based on the histological morphology and similarity of their differentiated glia cells. Traditionally, they are classified according to the World Health Organization and include astrocytomas, oligodendrogliomas, ependymomas, and oligoastrocytomas. Li.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.6
- DOI:
- 10.4238/2015.June.12.6
Association between rs1049673 polymorphism in CD36 and premature coronary heart disease
Authors: J.J. Che, Y.X. Shao, G.P. Li
Risk factors for premature coronary heart disease in China can be multiple; we investigated Chinese Han patients with premature coronary heart disease and a possible association with CD36 polymorphism at rs1049673, rs7755, and rs321159 sites. Outpatients were recruited according to chest X-ray coronary arteriography results; t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.8
- DOI:
- 10.4238/2014.September.26.8
Molecular identification and genetic variation of varieties of Styphnolobium japonicum (Fabaceae) using SRAP markers
Authors: R.X. Sun, C.H. Zhang, Y.Q. Zheng, Y.C. Zong, X.D. Yu and P. Huang
Thirty-four Styphnolobium japonicum varieties were analyzed using sequence-related amplified polymorphism (SRAP) markers, to investigate genetic variation and test the effectiveness of SRAP markers in DNA fingerprint establishment. Twelve primer pairs were selected from 120 primer combinations for their reproducibility and hig.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027837
- DOI:
- 10.4238/gmr.15027837
IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population
Authors: G.Q. Sun, G.D. Wu, Y. Meng, B. Du and Y.B. Li
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between Janu.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.9
- DOI:
- 10.4238/2014.September.26.9
BK polyomavirus association with colorectal cancer development
Authors: M.N. Khabaz, T. Nedjadi, M.A. Gari, J.A. Al-Maghrabi, H.M. Atta, A.A. Basuni and D.A. Elderwi
The development of human neoplasms can be provoked by exposure to one of several viruses. Burkitt lymphoma, cervical carcinoma, and hepatocellular carcinoma are associated with Epstein-Barr, human papilloma, and hepatitis B virus infections, respectively. Over the past three decades, many studies have attempted to establish an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027841
- DOI:
- 10.4238/gmr.15027841
Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients
Authors: X.Z. Cai, N. Liu,Y. Qiao, S.Y. Du, Y. Chen, D. Chen, S. Yu and Y. Jiang
Increasing evidence shows that TIM-1 and TIM-3 influence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown. Real-time transcription-polymerase chain reaction analysis was used to determine expression levels of TIM-1 and TIM-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 36 patient.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.7
- DOI:
- 10.4238/2015.June.12.7
Clinical and genetic analyses of Chinese patients with Gitelman syndrome
Authors: M. Miao, C.Q. Zhao, X.L. Wang and Z.Y. Shan
To evaluate the genotype-phenotype relationship of Gitelman syndrome in Chinese patients. We selected patients with Gitelman syndrome presenting hypokalemia. Medical history, clinical manifestations, laboratory test results, and imaging data of these patients were collected for analysis. Target gene sequencing was performed to.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027859
- DOI:
- 10.4238/gmr.15027859
Cloning and association analysis of KIT and EDNRB polymorphisms with dominant white coat color in the Chinese raccoon dog (Nyctereutes procyonoides procyonoides)
Authors: S.Q. Yan, C.Y. Bai, S.M. Qi, M.L. Li, S. Si, Y.M. Li and J.H. Sun
The Chinese raccoon dog (Nyctereutes procyonoides procyonoides) is one of the most important fur-bearing animal species. The dominant white individual, a coat color variant in farmed Chinese raccoon dog, shows a completely white phenotype over the entire body. The KIT and EDNRB genes have been reported to be associated with the dominant white coat color i.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.8
- DOI:
- 10.4238/2015.June.12.8
Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma
Authors: H.Y. Lu, G.L. Zhao, M.F. Fu
It has been proven that vascular endothelial growth factor (VEGF) is involved in airway restoration and the development of asthma. We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. We extracted the whole genomic DNA from the peripheral blood of 471 participants, including 22.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027859
- DOI:
- 10.4238/gmr.15027859
Antimicrobial activity of fermented Theobroma cacao pod husk extract
Authors: R.X. Santos, D.A. Oliveira, G.A. Sodr�©, G. Gosmann, M. Brendel and C. Pungartnik
Theobroma cacao L. contains more than 500 different chemical compounds some of which have been traditionally used for their antioxidant, anti-carcinogenic, immunomodulatory, vasodilatory, analgesic, and antimicrobial activities. Spontaneous aerobic fermentation of cacao husks yields a crude husk extract (CHE) with ant.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.10
- DOI:
- 10.4238/2014.September.26.10