Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population
Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu
ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025866
- DOI:
- 10.4238/gmr.15025866
Lack of association of functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in the Chinese population based on a case-control study and a meta-analysis
Authors: L.J. Qin, J. Wen, Y.L. Qu and Q.Y. Huang
Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotyp.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.9
- DOI:
- 10.4238/2013.September.3.9
Genetic diversity of Palestine landraces of faba bean (Vicia faba) based on RAPD markers
Authors: R. Basheer-Salimia, M. Shtaya, M. Awad, J. Abdallah and Y. Hamdan
Until now, neither phenotypic nor molecular approaches have been used to characterize the landraces of Palestine faba beans (Vicia faba). We used PCR-based RAPD markers to determine the genetic diversity and relatedness among 26 Palestinian faba bean landraces (traditional farmers’ varieties) from 8 localities in the West Bank, Palestine. In tests w.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.8
- DOI:
- 10.4238/2013.September.3.8
Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue
Authors: X. Han, W.L. Liang, Y. Zhang, L.D. Sun and W.Y. Liang
We investigated the effect of atmospheric fine particles on epidermal growth factor receptor (Egfr) mRNA expression in mouse skin tissue and explored the effect of atmospheric fine particles on skin aging. Forty female BALB/c mice were randomly divided into four groups (each comprising 10 mice) as follows: a saline control gro.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017188
- DOI:
- 10.4238/gmr.15017188
Epidemiology, species distribution, antifungal susceptibility, and ERG11 mutations of Candida species isolated from pregnant Chinese Han women
Authors: L. Yang, M.Q. Su, Y.Y. Ma, Y.J. Xin, R.B. Han, R. Zhang, J. Wen and X.K. Hao
The widespread use of antifungal agents has led to increasing azole resistance in Candida species. A major azole-resistance mechanism involves point mutations in the ERG11 gene, which encodes cytochrome P450 lanosterol 14a-demethylase. In this study, vaginal swabs were obtained from 657 pregnant Chinese Han women and cultured .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027168
- DOI:
- 10.4238/gmr.15027168
Cloning and molecular characterization of a cDNA encoding a small GTPase from Hevea brasiliensis
Authors: H.L. Li, D. Guo, W.M. Tian and S.Q. Peng
Small GTPases play a critical role in the regulation of a range of cellular processes including growth, differentiation, and intracellular transportation. The cDNA encoding a small GTPase, designated as HbGTPase1, was isolated from Hevea brasiliensis. HbGTPase1 was 882 bp long containing a 612-bp open reading frame encoding a putative protein of 203 amino.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.7
- DOI:
- 10.4238/2013.September.3.7
Single nucleotide polymorphisms in the CXCR1 gene and its association with clinical mastitis incidence in Polish Holstein-Friesian cows
Authors: J. Pokorska, M. Dusza, D. Ku��aj, K. �»ukowski and J. Makulska
The aim of this study was to identify the association between single nucleotide polymorphisms (SNPs) in the bovine chemokine receptor (CXCR1) gene and the resistance or susceptibility of cows to mastitis. The analysis of the CXCR1 polymorphism was carried out using polymerase chain reaction restriction fragment length polymorp.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027247
- DOI:
- 10.4238/gmr.15027247
DNA detection of Clostridium difficile infection based on real-time resistance measurement
Authors: C. Liu, D.N. Jiang, G.M. Xiang, F.K. Luo, L.L. Liu, J.C. Yu and X.Y. Pu
We used a newly developed electrochemical method, real-time resistance measurement, based on loop-mediated isothermal amplification (LAMP), with real-time resistance monitoring and derivative analysis. DNA extracted from specimens was amplified through LAMP reaction. The 2 products of LAMP, DNA and pyrophosphate, both are negative ions; they combine with .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.6
- DOI:
- 10.4238/2013.September.3.6
Association of glutathione S-transferase (GST) genetic polymorphisms with treatment outcome of cisplatin-based chemotherapy for advanced non-small cell lung cancer in a Chinese population
Authors: H.L. Xiao, Z.T. Yang, F. Han and H.X. Wei
The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) wer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027320
- DOI:
- 10.4238/gmr.15027320
Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population
Authors: L.J. Liu, X.Y. Zhang, N. He K Liu, X.G. Shi, T. Feng, T.T. Geng, D.Y. Yuan, L.L. Kangand T.B. Jin
Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027381
- DOI:
- 10.4238/gmr.15027381