Development of swine-specific DNA markers for biosensor-based halal authentication
Authors: M.E. Ali, U. Hashim, M. Kashif, S. Mustafa, Y.B. Che Man and S.B. Abd Hamid
The pig (Sus scrofa) mitochondrial genome was targeted to design short (15-30 nucleotides) DNA markers that would be suitable for biosensor-based hybridization detection of target DNA. Short DNA markers are reported to survive harsh conditions in which longer ones are degraded into smaller fragments. The whole swine mitochondr.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.9
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.9
Retrospective analysis of live birth prevalence of children with Down syndrome in Denizli, Turkey
Authors: Retrospective analysis of live birth prevalence of children with Down syndrome in Denizli, Turkey
Down syndrome (DS) is the most frequent chromosome abnormality among live births. Its prevalence increases with maternal age, and can be diagnosed by antenatal screening. We examined prevalence variations of DS in Denizli, Turkey, through a retrospective study. Sixteen years of survey data were retrieved from the two main state hospital registries from re.. Read More»
- Genet. Mol. Res. 11(4):
Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance
Authors: R.C. Xing, J. Zheng, W.H. Zheng, Z.P. Qin, W. Liu and R.C. Yao
We examined the effect of E-cadherin expression on epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) molecular targeted therapy sensitivity/resistance. We treated MCF-7, MDA-MB-231, T24, SiHa, H460, SK-HEP-1, MHCC97-H, and THP- 1 cells with the EGFR-TKIs PD153035 and gefitinib, and then tested the drug-resistance and sensitivity using .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.10
- DOI:
- 10.4238/2015.May.29.10
Changes in peripheral blood Th1 and Th2 cells in rat liver transplantation under different immune statuses
Authors: Z.-L. Yang, K. Cheng, H.G. Sun, W.W. Zou and M.M. Wu
In this study, early expressions of peripheral blood Th1 and Th2 cells were documented following rat liver transplantation and related to immune status. Rats were divided into 3 groups: group A (control): syngeneic transplantation (Brown Norway (BN) → BN); group B: allogeneic transplantation + cyclosporine A (CsA); group C: allogeneic transplantation.. Read More»
- Genet. Mol. Res. 12(4):
- http://dx.doi.org/2013.December.19.13
- DOI:
- http://dx.doi.org/10.4238/2013.December.19.13
Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression
Authors: W-J. Teng, P. Chen, F.-Y. Zhu, K. Di, C. Zhou, J. Zhuang,X.-J. Cao, J. Yang, L.-J. Deng and C.-G. Sun
We observed the influence of different concentrations of Rhizoma paridis total saponins (RPTS) on the apoptosis of colorectal cancer cells and explored the internal mechanism involved. We determined whether RPTS influences the interleukin-6 (IL-6)/Janus kinase (JAK)- signal transducer and activator of transcription-3 (STAT3) apoptosis molecular pathway an.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.11
- DOI:
- 10.4238/2015.May.29.11
Correlation between ERCC1 expression and concurrent chemotherapy and radiotherapy in patients with locally advanced nasopharyngeal cancer
Authors: R. Liang, Y. Lin, Z.H. Liu, X.L. Liao, C.L. Yuan, S.N. Liao and Y.Q. Li
In this study, the expression of DNA excision repair cross-complementing gene 1 (ERCC1) in local advanced nasopharyngeal carcinoma has been correlated with the efficacy of concurrent chemoradiotherapy. A total of 76 patients diagnosed with undifferentiated nasopharyngeal carcinoma diagnosed by nasopharyngeal biopsy and undergoing single-agent cisplatin ch.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.12
- DOI:
- 10.4238/2015.May.29.12
Human papillomavirus infection in Brazilian women with normal cervical cytology
Authors: P.M. Miranda, B.C.V. Pitol, M.S. Moran, N.N.T. Silva, P.M. Felix, J.L. Lima-Filho, C.M. Carneiro, I.D.C.G. Silva, R.F. Carvalho, A.A. Lima, W. Be�§ak and R.C. Stocco
We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples .. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.8
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.8
Characterization of Ty1/copia-like retrotransposon families from pigeonpea genome
Authors: P.G. Patil, M. Byregowda, I.O. Agbagwa and H.E. Shashidhar
Retrotransposons contribute significantly to the size, organization, and genetic diversity of their host genomes. To characterize novel retrotransposon families in pigeonpea and develop retrotransposon-based sequence-specific amplification polymorphic markers, in silico homology sequence search was carried out against the whole genome shotgun sequence of .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.13
- DOI:
- 10.4238/2015.May.29.13
RAPD and ISSR-assisted identification and development of three new SCAR markers specific for the Thinopyrum elongatum E (Poaceae) genome
Authors: G.H. Xu, W.Y. Su, Y.J. Shu, W.W. Cong, L. Wu and C.H. Guo
Diploid Thinopyrum elongatum, a wild relative of wheat, contains many agronomically desirable traits and has potential for increasing genetic variability and introducing desirable characters in this crop. Few molecular markers are available for rapid screening of T. elongatum genome segments in the wheat genetic background. We.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.7
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.7
Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer
Authors: W.X. Li, H.W. Xiao, X.Q. Hong and W.X. Niu
specimens and intraperitoneal drainage fluids, CK20 levels were lower in patients with earlier cancer stages than in those at later stages. During postoperative follow-up, serum negative CK20 patients had significantly higher 3-year survival rates than serum positive CK20 patients. All differences were statistically significant (P < 0.05). CK20 levels .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.14
- DOI:
- 10.4238/2015.May.29.14