Induction function of siRNA-mediated survivin gene silencing on nasopharyngeal carcinoma cell apoptosis
Authors: S.M. Fu, Z.H. Tu, L.Q. Deng, J.H. Cai, Z. Liang, Z.Q. Lin and Y.T. Wang
We examined the function of survivin gene expression in patients with nasopharyngeal carcinoma (NPC), as well as small interfering RNA (siRNA) on controlling CNE-2 NPC proliferation and apoptosis. Immunohistological methods, in situ hybridization, and reverse transcription-polymerase chain reaction technique were used to detect survivin protein and mRNA e.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.12
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.12
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells
Authors: C. Zhao, Z.G. Ma, S.L. Mou, Y.X. Yang, Y.H. Zhang, W.C. Yao
MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019281
- DOI:
- 10.4238/gmr16019281
Expression of LTP genes in response to saline stress in rice seedlings
Authors: G.P. Moraes, L.C. Benitez, M.N. do Amaral, I.L. Vighi, P.A. Auler, L.C da Maia, V.J. Bianchi and E.J.B. Braga
Saline stress is one of the primary factors limiting increased rice productivity in the southern region of Brazil. Farming can be affected by salinity that is due to both the origin of the soils as well as the irrigation water. Lipid transfer proteins (LTPs) have many physiological functions, including in the response to saline stress. Therefore, the obje.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.18
- DOI:
- 10.4238/2015.July.27.18
Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population
Authors: W. Wan, X. Xu, D.B. Zhao, Y.F. Pang and Y.X. Wang
In this study, we analyzed single nucleotide polymorphisms (SNP) in urate transporter genes to examine the pathogenesis of gout. We conducted a 1:1-matched case-control study that included 110 patients with acute gout attacks as the patient group and 110 healthy age- and gender-matched subjects as the control group. Clinical parameters were recorded and b.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.13
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.13
Isolation and characterization of microsatellite loci for the herbaceous tuber crop, Amorphophallus konjac (Araceae)
Authors: C. Pan Y.N. You Y. Diao Z.L. Hu J.M. Chen
Amorphophallus konjac is an herbaceous tuber crop with tremendous potential for commercial development. We report the development of microsatellite primers for this important crop species. Thirteen polymorphic microsatellite markers were developed and tested in two populations of A. konjac from the Wuling Mountain Region (WL p.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.17.8
- DOI:
- 10.4238/2012.October.17.8
Development and characterization of microsatellite markers via cross-species amplification of Paramisgurnus dabryanus
Authors: G. Chen, S. Huang, J. Gao, X. Bai, W. Wang and X. Cao
The large-scale loach, Paramisgurnus dabryanus, is a small freshwater fish of major economic importance in many Asian countries, particularly China and South Korea. Fifteen polymorphic microsatellite (simple sequence repeat) markers were obtained through cross-species amplification between this loach and a related species, Misgurnus anguillicaudatus (GenB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.1
- DOI:
- 10.4238/2015.May.29.1
Leaf transcriptome analysis and development of SSR markers in water chestnut (Eleocharis dulcis)
Authors: H.B. Liu, Y.N. You, Z.X. Zhu, X.F. Zheng, J.B. Huang, Z.L. Hu and Y. Diao
Water chestnut (Eleocharis dulcis) is an important aquatic crop in China; however, transcriptomic and genomic data in public databases are limited. To identify genes and development molecular markers, high-throughput transcriptome sequencing was applied to generate transcript sequences from water chestnut leaf. More than 24 million reads were obtained, tr.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.20
- DOI:
- 10.4238/2015.July.27.20
Impact and significance of EGCG on Smad, ERK, and �²-catenin pathways in transdifferentiation of renal tubular epithelial cells
Authors: C.G. Zhao, P. Zhou and Y.B. Wu
We investigated the impact and signal transduction mechanisms of epigallocatechin-3-gallate (EGCG) on transdiffer-entiation of renal tubular epithelial cells. Rat renal tubular epithelial cells (NRK-52E) were randomly divided into a normal control group, transforming growth factor (TGF)-b1-induced group (10 ng/mL), and intervention groups with 200 mg/L EG.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.14
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.14
Sexual dimorphism of STGC3 tumor suppressor function in nasopharyngeal carcinoma CNE2 cells
Authors: Q. Qiu B. Hu Z.C. Chen X.S. He
STGC3 is a potential tumor suppressor in nasopharyngeal carcinoma. We previously found that CNE2 cells that re-expressed STGC3 formed smaller tumors in female mice than in male mice. Here, we investigated the sexual dimorphism of STGC3 as a tumor-suppressor in female and male nude mice injected subcutaneously with pcDNA3.1(+)-.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.9.9
- DOI:
- 10.4238/2012.October.9.9
Identification of genes related to floral organ development in pak choi by expression profiling
Authors: H.X. Song, A.M. Ping, M.X. Sun, X.H. Qi, M.Y. Gao, X.Y. Xu,Z.J. Zhu, M.L. Li and L.P. Hou
Pak choi is a highly nutritious vegetable that is widely grown in China, Southeast Asia, and other parts of the world. Because it reproduces by seed, it is very important to understand the mechanism of floral organ development. Therefore, using the Chinese cabbage genome as a reference, this study analyzed the expression profi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019233
- DOI:
- 10.4238/gmr16019233