Expression of drought tolerance genes in tropical upland rice cultivars (Oryza sativa)
Authors: R.D.D. Silveira, F.R.M. Abreu, S. Mamidi, P.E. McClean, R.P. Vianello, A.C. Lanna, N.P. Carneiro and C. Brondani
Gene expression related to drought response in the leaf tissues of two Brazilian upland cultivars, the drought-tolerant Douradão and the drought-sensitive Primavera, was analyzed. RNA-seq identified 27,618 transcripts in the Douradão cultivar, with 24,090 (87.2%) homologous to the rice database, and 27,221 transcripts in the Primavera cultiv.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.6
- DOI:
- 10.4238/2015.July.27.6
Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer
Authors: W.X. Hu, C.M. Ding, R.J. Li, H.Y. Fan, Z.J. Guo and W. Liu
The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) pa.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.9
MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis
Authors: X.Y. Shi and Q. Shen
Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were ret.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.8
- DOI:
- 10.4238/2015.July.27.8
Construction of recombinant human IFN�±-2b BCG and its antitumor effects on bladder cancer cells in vitro
Authors: E. Sun, X. Nian, C. Liu, X. Fan and R. Han
We constructed recombinant Bacille Calmette-Guérin (rBCG) that secreted human interferon alpha 2b (hIFNa-2b), and investigated its antitumor effects on bladder cancer cells in vitro. The recombinant plasmid phIFN-a-2b was constructed using pMAO-4 and transformed into BCG. The supernatant was collected at various times and IFN-g, interleukin (IL)-12.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.7
Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors
Authors: H.Y. Zhang, X.B. Cheng, Y. Li, L.D. Jin, H.P. Yin
Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor eff.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019486
- DOI:
- 10.4238/gmr16019486
Effect of generations and environments in the analysis of a partial diallel to improve bean earliness
Authors: N.M. Vale, L.D. Barili, M.H. Souza, L.M.M. Moura, J.E.S. Carneiro, P.C. Carneiro and F.L. Silva
The objective of this study was to select genitors based on F1 and F2 generations, evaluated in different environments, to obtain segregating populations for the identification of strains showing improved earliness, yield, and carioca-type grains. Nine bean strains were crossed in a partial diallel scheme (4 x 5), in which group 1 included 4 strains with .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.9
- DOI:
- 10.4238/2015.July.27.9
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population J.
Authors: J.M. Liu, S.H. Cheng, C. Xia, T. Deng, Y.C. Zhu, X. Wei, Z.L. Huang, B.H. Liao, D.Y. Luo, Y.G. Zhang, T. Jin, K.J. Wang, J. Huang, H. Li
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated be.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019469
- DOI:
- 10.4238/gmr16019469
Gene expression of coffee seed oxidation and germination processes during drying
Authors: G.C. Santos, E.V.R. von Pinho and S.D.V.F. Rosa
Coffee (Coffea arabica L.) seeds are sensitive to desiccation and oxidative stress during drying processes. We investigated the effect of drying and moisture levels on germination-related gene expressions associated with enzymatic systems that prevent oxidative stress in coffee seeds. Coffee seeds collected at physiological maturity were subjected to slow.. Read More»
- Genet. Mol. Res. 12(4):
- 2013
- DOI:
- 10.4238/2013
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis
Authors: J.H. Sung, B.E. Lee2, J.O. Kim2, Y.J. Jeon2, S.H. Kim1, S.W. Lim, J.Y. Moon, D.H. Cha, O.J. Kim, I.J. Kim and N.K. Kim
Coronary artery disease (CAD), a multifactorial disease, is a common cause of mortality in humans. Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk. However, the sample size of this previous study was too small and limited to comprehensively define .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis
Authors: C.-P. Li, J.-H. Li, S.-Y. He, O. Chen and L. Shi
The aim of this study was to determine the therapeutic effect of curcumin on dextran sulfate sodium-induced ulcerative colitis (UC) and to explore the related mechanism. Sixty mice were randomly divided into 6 groups. A group was the normal control group; B group was the model group; C group was the 1.5 mg/kg dexamethasone group based on the B group; and .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.8