DNA polymorphisms of the Hu sheep melanocortin-4 receptor (MC4R) gene associated with birth weight and 45d-weaning weight
Authors: X.M. Song J.F. Jiang G.Z. Zhang F.X. Shi Y.Q. Jiang
The melanocortin-4 receptor (MC4R) has important roles in regulating food intake, energy balance, and body weight in mammals. In pigs and cattle, MC4R mutations have been identified as genetic markers for growth and traits. Compared with abundant research conducted on other livestock species, little is known about mutations of the ovine MC4R gene. We inve.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.27.3
- DOI:
- 10.4238/2012.September.27.3
Phylogenetic analysis reveals gene conversions in multigene families of rhizobia
Authors: J.E. Hernandez-Salmeron and G. Santoyo
Gene families are an important and intrinsic trait of rhizobial species. These gene copies can participate in non-reciprocal recombination events, also called gene conversions. Gene conversion has diverse roles, but it is usually implicated in the evolution of multigene families. Here, we searched for gene conversions in multi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1118
- DOI:
- 10.4238/vol10-3gmr1118
Genetic characterization of Brazilian strains of Aspergillus flavus using DNA markers
Authors: P.P. Batista, J.F. Santos, N.T. Oliveira, A.P.D. Pires, C.M.S. Motta and E.A. Luna-Alves Lima
The Aspergillus genus belongs to a filamentous fungal group characterized by wide dispersion in the environment. Some species are associated with diseases, especially in immunocompromised patients, while others are of economical importance due to aflatoxin production or biotechnological applications. Its species identification.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3gmr422
- DOI:
- 10.4238/vol7-3gmr422
Population genetics analysis of Podocnemis sextuberculata (Testudines, Podocnemidae): lack of population structure in the central Amazon Basin
Authors: T.J. Silva, L.A.S. Monjel�³, M.N.S. Viana, J.C. Pezzuti, P.C.M. Andrade, R.C. Vogt and I.P. Farias
The chelonians are, in general, important for the economy of the traditional populations of the Amazon region, especially as a source of animal protein. Furthermore, sub-products, such as eggs and fat, are utilized in the manufacture of cosmetics, and the plastron and carapace are used in the manufacture of adornments. The fre.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1163
- DOI:
- 10.4238/vol10-3gmr1163
Association between expression of DNA mismatch repair genes and clinical features and prognosis of patients with radical resection of colon cancer
Authors: J.B. Wang, D.L. Ma, J.Y. Li, Q.D. Sun and Y.E. Liu
The aim of this study was to investigate the clinical significance of the expression of DNA mismatch repair (MMR) genes in patients subjected to radical surgical removal of colon cancer, as well as their correlation with disease prognosis. Ninety stage II and III colon cancer patients who received laparoscopic radical resection of colon cancer at our hosp.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038388
- DOI:
- 10.4238/gmr.15038388
Mutation in intron 5 of GTP cyclohydrolase 1 gene causes dopa-responsive dystonia (Segawa syndrome) in a Brazilian family
Authors: C.P. Souza, E.R. Valadares, A.L.C. Trindade, V.L. Rocha, L.R. Oliveira and A.L.B. Godard
Dopa-responsive dystonia (DRD), also known as Segawa syndrome or hereditary progressive dystonia with diurnal fluctuation, is clinically characterized by the occurrence of simultaneous or late Parkinsonism and by an excellent response to treatment with low doses of L-dopa. Diagnosis of DRD is essentially clinical. It is based .. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3gmr467
- DOI:
- 10.4238/vol7-3gmr467
Evaluation of genetic diversity and population structure in a commercially important freshwater fish Prochilodus costatus (Characiformes, Prochilodontidae) using complex hypervariable repeats
Authors: T.M. Barroca G.B. Santos N.V.R. Duarte E. Kalapothakis
We used complex hypervariable repeats to evaluate the genetic diversity and structure of Prochilodus costatus (Characiformes), an ecologically and economically important species endemic to the São Francisco River basin. Hydroelectric dams along the river have led to population fragmentation, which can limit gene flow. Restocking from hatcheries has.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.27.4
- DOI:
- 10.4238/2012.September.27.4
Heterologous amplification and characterization of microsatellite markers in the Neotropical fish Leporinus friderici
Authors: A.M. Olivatti, T.A. Boni, N.J. Silva-J�ºnior, L.V. Resende, F.O. Gouveia and M.P.C. Telles
Leporinus friderici, native to the Amazon Basin and popularly known as “piau-três-pintas”, has great ecological and economic importance; it is widely fished and consumed throughout much of tropical South America. Knowledge of the genetic diversity of this native species is important to support management and .. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1020
- DOI:
- 10.4238/vol10-3gmr1020
Evolution of the SEC1 gene in New World monkey lineages (Primates, Platyrrhini)
Authors: B.N. Borges, T.S. Paiva and M.L. Harada
The structure and evolution of the SEC1 gene were examined for the first time in New World primates of the genera Alouatta, Aotus, Ateles, Brachyteles, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri. This gene has a high CG content (63.8%) and an estimated heterogeneous si.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3gmr452
- DOI:
- 10.4238/vol7-3gmr452
Identification of a DNA methylation point in the promoter region of the bovine CYP21 gene
Authors: A.M. da Silva, M.A.R. de Freitas, A.F.L. Rios, A. Renzi, R.B. L�´bo, M.A.V. Galerani, R.A. Vila and E.S. Ramos
The CYP21 (steroid 21-hydroxylase) gene is involved in the synthesis of steroid hormones. Bov-A2 is a retroposon that is common in ruminant genomes. The promoter region of bovine CYP21 contains a short interspersed nucleotide element of Bov-A2, which overlaps a putative Sp1 binding site. We looked for RFLP/HpaII polymorphism i.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1266
- DOI:
- 10.4238/vol10-3gmr1266