Missense mutation of the EDA gene in a Jordanian family with X-linked hypohidrotic ectodermal dysplasia: phenotypic appearance and speech problems
Authors: O.F. Khabour, F.S. Mesmar, F. Al-Tamimi, O.B. Al-Batayneh and A.I. Owais
Mutations in the EDA gene are responsible for X-linked hypohidrotic ectodermal dysplasia, the most common form of ectodermal dysplasia. Males show a severe form of this disease, while females often manifest mild to moderate symptoms. We identified a missense mutation (c.463C>T) in the EDA gene in a Jordanian family, using d.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr810
- DOI:
- 10.4238/vol9-2gmr810
Genetic structure and genetic diversity of single-variety Lonicera macranthoides populations in China, as indicated by SCoT markers
Authors: D.X. Chen, L.Y. Li, X. Zhang and Y. Wang
Lonicera macranthoides is an important traditional Chinese herb. The lack of information regarding the genetic structure and genetic relationships among its cultivars has hindered the conservation and utilization of this resource. This study used start codon targeted markers to assess the genetic diversity and other genetic characteristics of five single-.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.14
- DOI:
- 10.4238/2015.July.17.14
Correlation of spicule sign on computed tomography scans with peripheral lung cancers associated with interstitial lung disease and chronic obstructive pulmonary disease
Authors: L. Chen, L. Gao and W.L. Wu
The objective of this study was to investigate the correlation between spicular signs on computed tomography (CT) scans and peripheral lung cancer (PLC) that is associated with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). We analyzed clinical data from 96 PLC cases and grouped patients based on whether they had interst.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.9
- DOI:
- 10.4238/2015.March.27.9
Rapid determination of transgene copy number in tobacco by competitive PCR using a pair of SSR primers
Authors: K.Y. Xu, S.H. Wang, L. Xi, Q.J. Wang, C. Dong, J.Y. Zhang, S.C. Qu and Z. Zhang
We developed a straightforward, rapid, and inexpensive method to determine transgene copy number in tobacco. The plasmid (pSSRCopy) used for tobacco transformation contains a simple sequence repeat (SSR) locus, PT1199, which was partially deleted in the middle, a homogenous SSR locus in tobacco K326. A 168-bp segment of the cl.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr790
- DOI:
- 10.4238/vol9-2gmr790
Changes to the migratory inhibitory factor, IL-17, and IL-10 levels in serum from chronic hepatitis B patients and clinical significance following Baraclude�® treatment
Authors: X.-H. Yu, J.-C. Zhang, X.-Y. Li and T. Chen
This study aimed to determine the relationship between changes in the serum levels of macrophage migratory inhibitory factor (MIF), interleukin (IL) 17, and IL-10 during chronic hepatitis B treatment via Baraclude® (Bristol-Meyers Squibb). Thirty-six patients with chronic hepatitis B and 24 healthy individuals were selected as the experimental and con.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.16
Association of SSR markers with contents of fatty acids in olive oil and genetic diversity analysis of an olive core collection
Authors: M. Ipek, A. Ipek, M. Seker and M.K. Gul
The purpose of this research was to characterize an olive core collection using some agronomic characters and simple sequence repeat (SSR) markers and to determine SSR markers associated with the content of fatty acids in olive oil. SSR marker analysis demonstrated the presence of a high amount of genetic variation between the olive cultivars analyzed. A UPG.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.10
- DOI:
- 10.4238/2015.March.27.10
Stripe rust resistance and dough quality of new wheat - Dasypyrum villosum translocation lines T1DL�1V#3S and T1DS�1V#3L and the location of HMW-GS genes
Authors: W.C. Zhao, X. Gao, J. Dong, Z.J. Zhao, Q.G. Chen, L.G. Chen, Y.G. Shi and X.Y. Li
The transfer of agronomically useful genes from wild wheat species into cultivated wheat is one of the most effective approaches to improvement of wheat varieties. To evaluate the transfer of genes from Dasypyrum villosum into Triticum aestivum, wheat quality and disease resistance was evaluated in two new translocation lines, T1DL•1V#3S and T1DS&bul.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.16
- DOI:
- 10.4238/2015.July.17.16
Polymorphic microsatellite loci from two enriched genomic libraries for the genetic analysis of the miiuy croaker, Miichthys miiuy (Sciaenidae)
Authors: R.X. Wang, T.J. Xu, Y.N. Sun and G.Y. He
Twelve polymorphic microsatellites from the (AG)13 and (CA)13 enriched genomic libraries of Miichthys miiuy were isolated and characterized in a test population; the number of alleles ranged from two to nine. The observed and expected heterozygosities ranged from 0.1923 to 1.0000 and from 0.2633 to 0.8337, respectively. Three .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr806
- DOI:
- 10.4238/vol9-2gmr806
Preliminary in vitro analysis of mechanism of cardiac microvascular endothelial barrier function
Authors: W. Dong, G.N. Zhang and S.H. Gao
To preliminarily clarify the mechanism of cardiac microvascular endothelial barrier function leading to heart failure, primary HMVEC-D cells were selected and cultured for amplification. The cells were infected with adenovirus vector containing the ADP-ribosylation factor 6 (Arf6) Q67L gene. Full-length and functional fragment.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048864
- DOI:
- 10.4238/gmr15048864
Lentinan depresses 3T3-L1 fat cell formation by inhibiting PPAR�³/AKT signaling pathway
Authors: D.G. Li, J.L. Li, D.Q. Sun, X.B. Sun, X.G. Sun and Q. Liu
We investigated the mechanism of the effect of lentinan on 3T3-L1 fat cell formation by inhibiting the peroxisome proliferator-activated receptor gamma (PPARg)/protein kinase B (AKT) signaling pathway. 3T3-L1 fat cells were treated with 80 mM lentinan with or without the PPARg activator, 100 mM rosiglitazone for 24 h. Reverse transcription-polymerase chai.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.17
- DOI:
- 10.4238/2015.July.17.17