Comparison of methods for estimates of molecular genetic diversity in genus Croton: influence of coefficients, clustering strategies and data projection
Authors: M.M. Scaldaferri, J.S. Freitas, J.G.P. Vieira, Z.S. Gon�§alves, A.M. Souza and C.B.M. Cerqueira-Silva
We investigated 10 similarity (and disimilarity) coefficients in a set of 40 wild genotypes of Croton linearifolius subjected to analyses using hierarchical grouping methods, grouping methods by optimization and data projection in two-dimensional space. Genotypes were characterized by analyzing DNA polymorphism with t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.11
- DOI:
- 10.4238/2014.July.25.11
Treatment of moyamoya disease by multipoint skull drilling for indirect revascularization combined with mobilization of autologous bone marrow stem cells
Authors: R. Wu, N. Su, Z. Zhang and F. Jia
This study discusses the clinical efficacy of multipoint skull drilling for indirect revascularization combined with mobilization of autologous bone marrow stem cells and use of simvastatin in the treatment of moyamoya disease. Seventy-eight patients [control group (group A), 39 patients; experimental group (group B), 39 patients] with moyamoya disease we.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.27
- DOI:
- 10.4238/2015.July.3.27
Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis
Authors: Q.Y. Ning, J.Z. Wu, N. Zang, J. Liang, Y.L. Hu and Z.N. Mo
Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics o.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.10
- DOI:
- 10.4238/2011.December.14.10
Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis
Authors: T.-Y. Wang, S.-G. Liu, B.-S. Zhao, B. Qi, X.-G. Qin and W.-J. Yao
The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.12
- DOI:
- 10.4238/2014.July.25.12
Isolation and characterization of nucleotide-binding site and C-terminal leucine-rich repeat-resistance gene candidates in bananas
Authors: Isolation and characterization of nucleotide-binding site and C-terminal leucine-rich repeat-resistance gene candidates in bananas
Commercial banana varieties are highly susceptible to fungal pathogens, as well as bacterial pathogens, nematodes, viruses, and insect pests. The largest known family of plant resistance genes encodes proteins with nucleotide-binding site (NBS) and C-terminal leucine-rich repeat (LRR) domains. Conserved motifs in such genes in.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.15.1
- DOI:
- 10.4238/2011.December.15.1
A potential protective role for thiamine in glucose-driven oxidative stress
Authors: B. Palabiyik, F. Jafari Ghods and E. Onay Ucar
The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidati.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.13
- DOI:
- 10.4238/2014.July.25.13
Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and T.L. Dong
Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.28
- DOI:
- 10.4238/2015.July.3.28
Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis
Authors: D. Wu, Y. Wu, J.L. Liu3, B. Wang and X.D. Zhang
Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 p.. Read More»
- Genet. Mol. Res. 10(4):
Diagnosis of lymph node micrometastasis at the pN0 stage of lung adenocarcinoma using a combination of markers
Authors: H. Liu, Y.-K. Ye, G.-M. Li, Y. Zhou, K.-B. Han, G. Xu and D. Wang
This study aimed to detect micrometastatic tumor cells in the lymph nodes of patients with pN0 lung adenocarcinoma using a combination of thyroid transcription factor-1 (TTF-1) expression and cytokeratin 7 (CK7) expression and to investigate the association of lymph node micrometastasis with the clinicopathological characteris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.14
- DOI:
- 10.4238/2014.July.25.14
Inhibitory effects of a dendritic cell vaccine loaded with radiation-induced apoptotic tumor cells on tumor cell antigens in mouse bladder cancer
Authors: X.F. Xie, Q. Ding, J.G. Hou, G. Chen
Herein, the preparation of a dendritic cell (DC) vaccine with radiation-induced apoptotic tumor cells and its immunological effects on bladder cancer in C57BL/6 mice was investigated. We used radiation to obtain a MB49 cell antigen that was sensitive to bone marrow-derived DCs to prepare a DC vaccine. An animal model of tumor-bearing mice was established .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.30
- DOI:
- 10.4238/2015.July.3.30