Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats
Authors: Z. Chang, H.L. Wang and H. Du
Platinum-induced ovarian impairment is a consequence of treatment for malignant ovarian tumors. We compared the protective effects of Ginkgo flavonoids, amifostine, and leuprorelin on ovarian impairment in rats. Fifty rats were randomly divided into the A, B, C, D, and E groups, which were given saline, cisplatin, cis.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.6
- DOI:
- 10.4238/2014.July.24.6
Identification of microsatellite markers in coffee associated with resistance to Meloidogyne exigua
Authors: T.B. Pereira, T.A. Setotaw, D.N. Santos, A.N.G. Mendes, S.M.L. Salgado, G.R. Carvalho and R.M. Rezende
Meloidogyne species are destructive phytonematodes that result in reduced yields of coffee. The classic test for resistance to Meloidogyne exigua in coffee progenies is both expensive and time-consuming. The use of molecular marker techniques can assist the selection process when it is difficult to measure the phenotype, such as in cases of resistance to .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038054
- DOI:
- 10.4238/gmr.15038054
Association of NF-�ºB1 gene polymorphisms with coronary artery disease in a Han Chinese population
Authors: X.L. Guo, X.C. Liu, G.B. Su, C.Y. Zhou and Q.T. Cui
Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038072
- DOI:
- 10.4238/gmr.15038072
Efficacy of oral administration of lactic acid bacteria isolated from cocoa in a fermented milk preparation: reduction of colitis in an experimental rat model
Authors: T.F. dos Santos, T.A. Melo, D.S. Santos, R.P. Rezende, J.C.T. Dias and C.C. Romano
We investigated the probiotic potential of lactic acid bacteria (LAB) obtained from cocoa fermentation using an experimental rat model of colitis. Cocoa beans were collected from fermentation boxes every 12 h for 5 days to isolate the microorganisms. Strains were isolated by serial dilution and plating on MRS agar. Gram-positive and catalase-negative rods.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038097
- DOI:
- 10.4238/gmr.15038097
Expression profiles of genes associated with mitochondria-mediated apoptosis and their roles in liver regeneration
Authors: X.K. Xing, M.H. Li, Z.W. Guo and C.S. Xu
Mitochondria are closely associated with cell survival, and it is of interest to determine whether apoptosis pathways, which are mediated by mitochondria, are involved in liver regeneration (LR). To identify the mechanisms underlying mitochondria-mediated apoptosis during rat LR, we used the Rat Genome 230 2.0 Array to investigate changes in gene expressi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038101
- DOI:
- 10.4238/gmr.15038101
HydroCalc Proteome: a tool to identify distinct characteristics of effector proteins
Authors: G.J. da Silva, R.G.T.M. da Silva, V.A. Silva, E. C. Carit�¡, A.L. Fachin and M. Marins
Bacterial pathogenicity is associated with secretion of effector proteins into intra- and extracellular spaces. These proteins interfere with cellular processes such as inhibition of phagosome-lysosome fusion, induction of apoptosis and autophagy, activation and suppression of kinases, regulation of receptor activity, and modulation of transcription facto.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038111
- DOI:
- 10.4238/gmr.15038111
Effect of calcitonin on anastrozole-induced bone pain during aromatase inhibitor therapy for breast cancer
Authors: P. Liu, D.Q. Yang, F. Xie, B. Zhou and M. Liu
This study aimed to investigate calcitonin as an effective therapy for osteoporosis in patients with bone pain during the anastrozole treatment of breast cancer. Ninety-one patients, who were on anastrozole treatment for breast cancer and also suffered anastrozole-induced bone pain, were randomly divided into two groups: the c.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.7
- DOI:
- 10.4238/2014.July.24.7
Morphoagronomic characterization and genetic diversity of a common bean RIL mapping population derived from the cross Rud�¡ x AND 277
Authors: L.C. Silva, R.O. Batista, R.S.R. Anjos, M.H. Souza, P.C.S. Carneiro, T.L.P.O. Souza, E.G. Barros and J.E.S. Carneiro
Recombinant inbred lines (RILs) are a valuable resource for building genetic linkage maps. The presence of genetic variability in the RILs is essential for detecting associations between molecular markers and loci controlling agronomic traits of interest. The main goal of this study was to quantify the genetic diversity of a common beanRIL population deri.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038112
- DOI:
- 10.4238/gmr.15038112
Predictive role of RRM1 and BRCA1 mRNA expression on the clinical outcome of advanced non-small cell lung cancer
Authors: J.G. Liang, Z.Y. Jin, X.D. Gao, M.R. Te, L.H. Ge and C.L. Wang
This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients in terms of their response and prognosis. In total, 377 patients agreed to participate in our study, and all of them received plati.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.8
- DOI:
- 10.4238/2014.July.24.8
The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis
Authors: F. Yan, R. Wang and L. Geng
Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible st.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038172
- DOI:
- 10.4238/gmr.15038172