Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken
Authors: Y. Wei S.K. Zhu S. Zhang R.L. Han Y.D. Tian G.R. Sun X.T. Kang
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is rate-limiting for metabolism of cholesterol; it plays an important role in endogenous cholesterol biosynthesis. We used DNA sequencing technology and created restriction site PCR-RFLP to detect HMGCR SNPs in an F2 resource population of Gushi chicken and Anka broilers. We found a G/T mu.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.10
- DOI:
- 10.4238/2012.November.12.10
Characterization and development of 56 EST-SSR markers derived from the transcriptome of Odontobutis potamophila
Authors: P.P. Wang, M. Ren, S.Q. Chen, S.W. Yin, C. Zhao, H.Y. Zhang, X.R. Li, Q.Q. Cao and G.Q. Zhou
Expressed sequence tags (ETSs) are the sources of microsatellite development. In this study, we isolated and characterized microsatellite markers for Odontobutis potamophila by using Illumina RNA-sequencing. We sequenced a large number of ESTs and screened 200 potential microsatellites. Consequen.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029129
- DOI:
- 10.4238/gmr16029129
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis
Authors: H.Y. Cao, S. Yang, S. Wang, L.Y. Deng, J.Y. Lou
We conducted a meta-analysis to examine p16INK4a expression in uterine smooth muscle tumors (USMTs). Although the prognostic value of tumor suppressor p16INK4a has been elucidated in a variety of cancers and precancerous lesions, its role in USMTs is not well established. We searched PubMed, Web of Science, and Embase for publ.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019481We conducted a meta-analysis to examine p16INK4a expression i
- DOI:
- 10.4238/gmr16019481We conducted a meta-analysis to examine p16INK4a expression i
Assessment of the cytotoxic, genotoxic, and mutagenic potential of Acrocomia aculeata in rats
Authors: G.K. Traesel, L.H.A. Castro, P.V.B. Silva, R.M. Muzzi, C.A.L. Kassuya, A.C. Arena and S.A. Oesterreich
Acrocomia aculeata (Jacq.) Lodd. ex Mart. is a plant species commonly used as a foodstuff and also for treating diseases, since it contains high concentrations of antioxidant compounds and monounsaturated fatty acids. Considering its ethnopharmacological relevance, the aim of the present study was to assess the cytotoxic, genotoxic, and mutagenic effects .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.13
- DOI:
- 10.4238/2015.January.26.13
Genetic variation among quince(Cydonia oblonga Mill.) genotypes sampled from the Coruh valley in Turkey
Authors: E. Orhan G. Nardemir, G. Agarand S. Ercisli
Turkey has very rich quince genetic resources, and the country currently dominates world quince production. In particular, the northeastern part of the country has notable Cydonia oblonga Mill. germplasm. Authenticating the identity of germplasm resources of C. oblonga Mill. would be of great value for breeding practices. In t.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.12
- DOI:
- 10.4238/2014.January.21.12
DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis
Authors: R.B. Ji, Y.S. Qian, A.R. Hu, Y.R. Hu
Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.11
- DOI:
- 10.4238/2015.December.7.11
Pig KALRN, MYH1, MLC2V, SNX13, AK1, and PPIA loci RH mapping and chromosome position refining
Authors: C. Gorni1, S. Iacuaniello2, B. Castiglioni3, G. Pagnacco2 and P. Mariani
The suppressive subtractive hybridization technique was previously used by the authors to identify candidate genes for meat quality in pig. A set of ESTs homologous (>95%) to genes involved in muscle metabolism is reported in the present paper. Four ESTs homologous to MYH1, KALRN, MLC2V, and SNX13 genes plus two genes (AK1, PPIA) used as housekeeping f.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr471
- DOI:
- 10.4238/vol7-4gmr471
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of rats subjected to water immersion and restraint stress
Authors: 4788
The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis. We examined the expression and localization of IGF-1, PTEN, Akt, and FoxO .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.19.2
- DOI:
- 10.4238/2012.September.19.2
Intraspecific differentiation of Hancornia speciosa revealed by simple sequence repeat and random amplified polymorphic DNA markers
Authors: C.A. Nogueira, N.B. Stafuzza,T.P. Ribeiro, A.D.L. Prado, I.P.P. Meneze, N. Peixoto, P.J. Gon�§alves,L.M. Almeida
Hancornia speciosa, popularly known as mangabeira, is a fruit tree native to the Brazilian Cerrado that shows great economic potential, due to its multiple uses. Intraspecific classification of this species is difficult because it shows high morphological diversity. An early study of the species reported that there are six bot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.12
- DOI:
- 10.4238/2015.December.7.12
Agrobacterium-mediated transformation of tomato with the ICE1 transcription factor gene
Authors: J.X. Juan, X.H. Yu, X.M. Jiang, Z. Gao, Y. Zhang, W. Li,Y.D. Duan and G. Yang
ICE1 genes play a very important role in plants in cold conditions. To improve the cold resistance of tomato, the ICE1 gene of Arabidopsis thaliana was used to construct the plant expression vector p3301-ICE1, and was overexpressed in tomato through Agrobacterium-mediated transformation. Five strains of resistant plants were obtained. PCR and half-quantitati.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.1
- DOI:
- 10.4238/2015.January.30.1