NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the ris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.3
- DOI:
- 10.4238/2014.March.19.3
Construction of a tissue engineered intervertebral disc with high biological activity using an allogeneic intervertebral disc supplemented with transfected nucleus pulposus cells expressing exogenous dopamine beta-hydroxylase
Authors: M. Bai, Y.H. Wang, H.P. Yin and S.W. Li
This study addressed the in vitro construction and biological activity of tissue engineered intervertebral discs with exogenous human dopamine beta-hydroxylase (DBH) nucleus pulposus cells. pSNAV2.0-DBH expression plasmids were utilized to enhance the survival rates of intervertebral disc tissue cells. Various concentrations of transfected nucleus pulposu.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.6
Feline immunodeficiency virus and feline leukemia virus: frequency and associated factors in cats in northeastern Brazil
Authors: L.C. Lacerda, A.N. Silva, J.S. Freitas, R.D.S. Cruz, R.A. Said and A.D. Munhoz
Our aims were to determine the frequencies of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in owned and stray cats in the northeastern region of Brazil, ascertain the status of FeLV infection, and investigate potential associated factors among the owned cats. Blood samples from 200 asymptomatic owned ca.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029633
- DOI:
- 10.4238/gmr16029633
Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy
Authors: Zhang, W. Ma, Y. Li, J. Wu and G.Y. Shi
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on tre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.2
- DOI:
- 10.4238/2014.January.14.2
A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia
Authors: T.D. Zhong, Q. Liu, J.N. Zhao, H.W. Wang and A. Konstantatos
This study aimed to evaluate whether combined oral oxycodone hydrochloride-controlled release tablets plus paracetamol and tramadol hydrochloride tablets are more effective than epidural analgesia for postoperative pain control and side effects after cesarean section. We randomly enrolled 60 patients scheduled for cesarean sec.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.4
- DOI:
- 10.4238/2014.March.19.4
Identification and characterization of RFRP gene in pigs and its association with reproductive traits
Authors: M.X. Fang, Y.S. Huang, J. Ye, W. Zhang, Y. Li and Q.H. Nie
RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.8
- DOI:
- 10.4238/2014.January.14.8
GlpC gene is responsible for biofilm formation and defense against phagocytes and imparts tolerance to pH and organic solvents in Proteus vulgaris
Authors: Y.L. Wu, K.S. Liu, X.T. Yin and R.M. Fei
Biofilm-forming bacteria are highly resistant to antibiotics, host immune defenses, and other external conditions. The formation of biofilms plays a key role in colonization and infection. To explore the mechanism of biofilm formation, mutant strains of Proteus vulgaris XC 2 were generated by Tn5 random transposon insertion. Only one biofilm defective bac.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.3
Genetic differentiation between natural and hatchery populations of Manila clam (Ruditapes philippinarum) based on microsatellite markers
Authors: K. Xing, M.L. Gao and H.J. Li
Manila clam (Ruditapes philippinarum) is one of the major aquaculture species around the world and supports an important segment of the aquaculture industry in China. In this study, we used ten microsatellite markers to detect genetic diversity within six R. philippinarum populations and genetic differentiation between them. A.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.7
- DOI:
- 10.4238/2014.January.17.7
Survey of attitude and knowledge of reproductive health among middle school students in Luoyang, China
Authors: P. Wang, Y.J. Zhang, X.J. Pan, X.Y. Xia and S.Y. Lv
The aim of this study was to assess the knowledge and attitude of AIDS and sexual behavior of middle school students. Structural questionnaires were designed to interview 1980 junior and senior middle school students about their basic knowledge, attitude, and behavior with respect to AIDS and sexual behavior. Students were rec.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.17
- DOI:
- 10.4238/2014.March.24.17
Mutation analysis of a Chinese pedigree with triphalangeal thumb-polysyndactyly syndrome
Authors: X.S. Xing, H.W. Zhu, C. Chen, S.S. Wang, Y. Luo and X. Zhang
Triphalangeal thumb-polysyndactyly syndrome (TPTPS) is an autosomal dominant limb disorder with triphalangeal thumbs, polysyndactyly, and syndactyly. In this study, we describe a four-generation Han Chinese family with eight affected members. Haplotype analysis, Affymetrix SNP 6.0 arrays, qPCR, and gap-PCR were performed. Hapl.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.8
- DOI:
- 10.4238/2014.January.17.8