Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Authors: F.L. Campedelli, K.S.F. e Silva, D.A. Rodrigues, J.V.M. Martins, I.R. Costa, M.H. Lagares, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alteratio.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029550
- DOI:
- 10.4238/gmr16029550
Construction of a lentiviral vector encoding heme oxygenase 1 and its introduction into mouse adipose tissue-derived stem cells
Authors: C.H. Zhu, W. Lei and Z.R. Chen
Many studies exist concerning the use of stem cells as delivery vehicles in gene therapy, expressing genes such as vascular endothelial growth factor 165 and hepatocyte growth factor. However, few reports regarding adipose tissue-derived stem cells (ADSCs) and the heme oxygenase 1 (HO-1) gene have been published. Therefore, we established a lentiviral vec.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.10
Hsp70 gene polymorphisms in farmed marine shrimp Litopenaeus vannamei populations exposed to white spot disease and infectious myonecrosis
Authors: A.L. Ferreira Jr, R. Maggioni, D. Concei�§�£o, L.M. Perazzolo and R.L. Petersen
Single nucleotide polymorphisms (SNPs) are the best genetic markers for associative studies of the immune system in invertebrates. In the marine shrimp Litopenaeus vannamei, SNPs linked to disease resistance have been reported for some genes, such as hemocyanin, anti-lipopolysaccharide factor, and heat-shock protein 70 (Hsp70).. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029668
- DOI:
- 10.4238/gmr16029668
Mendelian inheritance, genetic linkage, and genotypic disequilibrium for nine microsatellite loci in Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae)
Authors: T.Y.K. Kubota, A.M. Silva, J. Cambuim, A.A. Silva, S. Pupin, M.S. Silva, M.A. Moraes, M.L.T. Moraes and A.M. Sebbenn
Cariniana estrellensis is one of the largest trees found in Brazilian tropical forests. The species is typical of advanced stages of succession, characteristic of climax forests, and essential in genetic conservation and environmental restoration plans. In this study, we assessed Mendelian inheritance, genetic linkage, and gen.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029653
- DOI:
- 10.4238/gmr16029653
Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4
Authors: F. PÃ?©rtille, R. Zanella, A.M. FelÃ?Âcio, M.C. Ledur, J.O. Peixoto and L.L. Coutinho
Genetic selection for production traits has resulted in a rapid improvement in animal performance and development. Previous studies have mapped quantitative trait loci for body weight at 35 and 41 days, and drum and thigh yield, onto chicken chromosome 4. We investigated this region for single nucleotide polymorphisms and their associations with important.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.11
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.11
Association of NR4A1 and GNB2L1 genes with reproductive traits in commercial pig breeds
Authors: T. Kumchoo and S. Mekchay
The nuclear receptor subfamily 4, group A, member 1 (NR4A1) and guanine nucleotide binding protein beta polypeptide 2 like-1 (GNB2L1) genes are expressed during the ovulatory process and in early pregnancy in pigs. The objective of this study was to analyze the effects of NR4A1 and GNB2L1 gene variants on reproductive traits in commercial pig breeds. Two .. Read More»
- Genet. Mol. Res. 14(4):
- DOI http://dx.doi.org/2015.December.8.18
- DOI:
- DOI http://dx.doi.org/10.4238/2015.December.8.18
Screening of differentially expressed genes in pathological scar tissues using expression microarray
Authors: L.P. Huang, Z. Mao, L. Zhang, X.X. Liu, C. Huang and Z.S. Jia
Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up- or down-regulated genes in 2-fold differentially expressed genes, 956.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.13
Production of hGFAP-DsRed transgenic Guangxi Bama mini-pigs via somatic cell nuclear transfer
Authors: L.L. Hu, Y.Q. Lu, H.Y. Xu, X.G. Yang, S.S. Lu and K.H. Lu
The mini-pig is a useful animal model for human biomedical research due to its physiological similarity to humans and the ease of handling. In order to optimize the efficiency of production of transgenic Bama mini-pigs through somatic cell nuclear transfer (SCNT), we examined the effects of contact inhibition, roscovitine treatment, and serum starvation o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.19
- DOI:
- 10.4238/2015.December.8.19
Expression of c-myc and mutation of the KRAS gene in patients with ovarian mucinous tumors
Authors: X.S. Li, J. Sun and X.L. He
We examined the expression of c-myc and mutations in the KRAS gene in ovarian mucinous tumors to explore the pathogenesis of these tumors and the feasibility of targeted gene therapy. Expression of c-myc protein and mutations in the KRAS gene in 24 cases of ovarian mucinous cystadenoma, 46 cases of ovarian borderline mucinous cystadenoma, and 46 cases of .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.14
Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis
Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang
Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.16