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Plant Genetics   Research Article
Genetic diversity and structure in Tunisian wild cherries and cultivated sweet cherries revealed by SSR markers

Authors: Azizi-Gannouni Thouraya, Ammari Youssef, Mnasri Rahmani Sameh, Ben Naceur M’barek, Albouchi Ali

Wild cherries are concentrated at high altitudes in northern Tunisia and cultivated sweet cherries are well adapted to low altitudes. This study aims to compare local wild and cultivated sweet cherries (Prunus avium L.) in the northern of Tunisia. To elucidate genetic variation of 21 cultivated sweet cherries (one landrace and 20 foreigner cultivars) .. Read More»

Genet. Mol. Res. 20(6):

Human Genetics   Review Article
Co-targeting the EGFR and PI3K/Akt pathway to overcome therapeutic resistance in head and neck squamous cell carcinoma: What about autophagy?

Authors: Hannah Zaryouh, Jinthe Van Loenhout, Marc Peeters, Jan Baptist,Vermorken, Filip Lardon, An Wouters

Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR-targeting agents to treat head and neck squamous cell carcinoma. The Epidermal Growth Factor Receptor (EGFR) is overexpressed in the majority of Head and Neck Squamous Cell Carcinomas (HNSCC). This triggered the development of multiple anti.. Read More»

Genet. Mol. Res. 20(6):

Human Genetics   Review Article
Optogenetic approach improves neuroregenerative potential of stem cell-based therapies

Authors: Zahra-Soheila Soheili, Hoda Shams Najafabadi

Neural cells represent very limited regenerative capacity and cannot prevent the progression of central nervous system, and retinal, neurodegenerative diseases such as Alzheimer's, Parkinson's, Retinitis pigmentosa or age related macular degeneration diseases. Stem cell based regenerative strategies revealed successful preclinical transplantation outco.. Read More»

Genet. Mol. Res. 20(6):

Human Genetics   Short communication
Mitochondrial sirtuins in cancer

Authors: Mitochondrial sirtuins in cancer

All living beings require energy and the ultimate source for this energy in eukaryotes are mitochondria – originally an organelle of bacterial origin and eventually incorporated into the cytoplasm. Mitochondrial bioenergetics and dynamics are essential for the maintenance of cellular and metabolic homeostasis and any imbalance can result in diseases.. Read More»

Genet. Mol. Res. 20(6):

Human Genetics   Editorials
A brief study about DNA polymerase

Authors: Mohammad irani hafeez

Ribonucleases (RNases) are key players of the host immunity and contribute to maintaining tissue homeostasis and body fluid sterility. Secreted upon a diversity of cellular injuries, they mediate signaling processes, and have been classified as alarmins. Recent literature reveals how the immune response system uses common strategies to fight both cance.. Read More»

Genet. Mol. Res. 20(6):

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