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Human Genetics   Research Article
Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues

Authors: H.B. Xia, H.W. Cui, L. Su, Z.H. Zhang, X.Y. Yang, S.Q. Ning and X.L. Su

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using im.. Read More»

Genet. Mol. Res. 16(3): gmr16039278

DOI: 10.4238/gmr16039278

Plant Genetics   Research Article
Variability among Capsicum baccatum accessions from Goi�¡s, Brazil, assessed by morphological traits and molecular markers

Authors: A.L.A. Martinez, J.S.P. Ara�ºjo, C.F. Ragassi, G.S.C. Buso and F.J.B. Reifschneider

Capsicum peppers are native to the Americas, with Brazil being a significant diversity center. Capsicum baccatum accessions at Instituto Federal (IF) Goiano represent a portion of the species genetic resources from central Brazil. We aimed to characterize a C. baccatum working collection comprising 27 accessions and 3 commerci.. Read More»

Genet. Mol. Res. 16(3): gmr16039074

DOI: 10.4238/gmr16039074

Plant Genetics   Research Article
An optimized protocol for DNA extraction in plants with a high content of secondary metabolites, based on leaves of Mimosa tenuiflora (Willd.) Poir. (Leguminosae)

Authors: S.R. Arruda, D.G. Pereira, M.M. Silva-Castro, M.G. Brito and A.M. Waldschmidt

Some species are characterized by a high content of tannins, alkaloids, and phenols in their leaves. These secondary metabolites are released during DNA extraction and might hinder molecular studies based on PCR (polymerase chain reaction). To provide an efficient method to extract DNA, Mimosa tenuiflora, an important legumino.. Read More»

Genet. Mol. Res. 16(3): gmr16039063

DOI: 10.4238/gmr16039063

Human Genetics   Research Article
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population

Authors: Z. Fang, M. Li, Z. Ma and G. Tu

Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»

Genet. Mol. Res. 16(3): gmr16037446

DOI: 10.4238/gmr16037446