Authors: A.H.N. Rangel, L.G. Zaros, T.C. Lima, L.H.F. Borba, L.P. Novaes, L.F.M. Mota and M.S. Silva
Several human health problems have been related to the allergenic constitution of bovine milk due to the body’s immune reaction to milk proteins. It is necessary find solutions to minimize the occurrence of such reactions, given the importance of milk as a source of animal protein. The aim of this study was to evaluate t.. Read More»
Genet. Mol. Res. 16(2): gmr16029592
DOI: 10.4238/gmr16029592
Authors: C.S.D. Morais, P.R.A.M. Affonso, J.A. Bitencourt and A.A. Wenceslau
This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterati.. Read More»
Genet. Mol. Res. 16(2): gmr16029433
DOI: 10.4238/gmr16029433
Authors: G.E. Yu, S. Kwon, J.H. Hwang, S.M. An, D.H. Park, D.G. Kang, T.W. Kim, I.-S. Kim, H.C. Park, J. Ha and C.W. Kim
Cell death-inducing DFF45-like effector (CIDE) B is a member of the CIDE family of apoptosis-inducing factors. In the present study, we detected a single nucleotide polymorphism (SNP), c.414G>A, which corresponds to the synonymous SNP 414Arg, in CIDE-B in the Berkshire pigs. We also analyzed the relationships between the CI.. Read More»
Genet. Mol. Res. 16(2): gmr16029408
DOI: 10.4238/gmr16029408
Authors: D. Zhao, C.-J. Zhang, R. Yang, J.-P. Chen, L. Ma, G. Liu and X.-P. Yang
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of c.. Read More»
Genet. Mol. Res. 16(2): gmr16029191
DOI: 10.4238/gmr16029191
Authors: T.D. Silva, C.M.A. Almeida, C.B. Malafaia, L.M.S. Oliveira, M.V. Silva and M.T.S. Correia
Fusarium wilt caused by Fusarium oxysporum f. sp lycopersici (Fol) is one of the main diseases affecting tomatoes. The BHRS 2,3 genotype of tomato is, however, resistant to this disease. A proteomic approach was used to understand the defense mechanisms of this genotype using the tomato root, the first tissue that interacts wi.. Read More»
Genet. Mol. Res. 16(2): gmr16027209
DOI: 10.4238/gmr16027209
Authors: L.R. Ruschel, V.M. Schmitt, A.B. Silva, C.S.A. Oliveira, K. Flach, D.O. d�Avila and F.V. Thiesen
Mycophenolate mofetil (MMF) is a prodrug active only after its hydrolysis to mycophenolic acid (MPA). The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms (SNPs) in the UGT1A9 gene may be responsible for individual differences in the pharma.. Read More»
Genet. Mol. Res. 16(2): gmr16029598
DOI: 10.4238/gmr16029598
Authors: C.F.B. S�¡nchez, P.E. Teodoro, S. Londo�±o, L.A. Silva, L.A. Peixoto and L.L. Bhering
Repeatability studies on fruit species are of great importance to identify the minimum number of measurements necessary to accurately select superior genotypes. This study aimed to identify the most efficient method to estimate the repeatability coefficient (r) and predict the minimum number of measurements needed for a more a.. Read More»
Genet. Mol. Res. 16(2): gmr16029594
DOI: 10.4238/gmr16029594
Authors: V.R.Z.B. Pereira, J.M. Wolf, G.Z. Stumm, T.R. Boeira, J. Galvan, D. Simon and V.R. Lunge
Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations.. Read More»
Genet. Mol. Res. 16(2): gmr16029565
DOI: 10.4238/gmr16029565