Animal Genetics
Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression
Authors: L. Meng, Z. Lv, Z.Z. Yu, D. Xu and X. Yan
This study aimed to explore the protective effect of quercetin on acute lung injury (ALI) in rats with sepsis and the related mechanism. Rats were administered different doses of quercetin intraperitoneally, and blood samples and lung tissue were collected at 24 h after treatment. Arterial blood gases, lung water content, protein content, and cell counts .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037265
- DOI:
- 10.4238/gmr.15037265
Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the keletal muscle of Dorper and Hu sheep hybrid F1 rams
Authors: H.J. Xing, Z.Y. Wang, B.S. Zhong, S.J. Ying, H.T. Nie, Z.R. Zhou, Y.X. Fan and F. Wang
MSTN, IGF-Ð?(insulin-like growth factor-Ð?) and IGF-II (insulin-like growth factor-II) regulate skeletal muscle growth. This study investigated the effects of different dietary intake levels on skeletal muscles. Sheep was randomly assigned to 3 feeding groups: 1) the maintenance diet (M), 2) 1.4 x the mai.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.4
- DOI:
- 10.4238/2014.July.24.4
Effects and mechanisms of Fenofibrate on the secretion of vascular endothelial contraction factors in hypertensive rats
Authors: Y. Zhu, H.-S. Wang, X.-M. Li and C. Qu
This study investigated the effects of the peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, Fenofibrate, on the secretion of vascular endothelial contraction factors in hypertensive rats to elucidate its possible mechanisms. The vascular ring contraction experiment was used to observe whether rat vascul.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.5
- DOI:
- 10.4238/2014.July.24.5
Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats
Authors: Z. Chang, H.L. Wang and H. Du
Platinum-induced ovarian impairment is a consequence of treatment for malignant ovarian tumors. We compared the protective effects of Ginkgo flavonoids, amifostine, and leuprorelin on ovarian impairment in rats. Fifty rats were randomly divided into the A, B, C, D, and E groups, which were given saline, cisplatin, cis.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.6
- DOI:
- 10.4238/2014.July.24.6
Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs
Authors: D. Purushothaman, W.Y. Brown, B.A. Vanselow, K. Quinn and S.-B. Wu
Long chain n-3 fatty acids are beneficial to mammals because of their anti-inflammatory role. However, whether flaxseed oil, which is rich in short chain n-3 fatty acids, has such a role, it has not been extensively examined. This study investigated the supplementation of flaxseed oil on the regulation of gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.11
- DOI:
- 10.4238/2014.July.24.11
Evidence of balancing selection in multiple indigenous chicken populations
Authors: S. Arlud, G.X. E and S.C. Zeng
Microsatellite DNA markers, which are assumed to drift, have been widely used to assess genetic diversity in all major domestic animal species. These markers provide insight into the arrival and dispersion history of a species, with regard to their content or management history. However, no direct evidence supports current standard microsatellite markers .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038249
- DOI:
- 10.4238/gmr.15038249
Development of microsatellite markers and genetic diversity analysis for Pelodiscus sinensis
Authors: T. Li, J. Zhao, W. Li, Y. Shi, X.Y. Hong and X.P. Zhu,
Pelodiscus sinensis is a common freshwater soft-shell turtle found in China, and is an important aquaculture species. In this study, 20 polymorphic microsatellite primers were developed from the transcriptome. The genetic diversity of three populations of P. sinensis was evaluated, using 72 individuals. The number of alleles per locus ranged from 3 to 26... Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038346
- DOI:
- 10.4238/gmr.15038346
Molecular cloning and expression analysis of the GNAS gene in pig and porcine fibroblast cells
Authors: J. Peng, Y.L. Li, Y.F. Shen, Y. Wang and N.Y. Xu
The Alpha subunit of the stimulatory guanine nucleotide-binding protein (GNAS) is a complex imprinted gene. The major product of the GNAS gene is the α-subunit of the guanine nucleotide-binding protein (Gas), which plays a key role in multiple signal transduction pathways. Gas is required for the production of the recept.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.26
- DOI:
- 10.4238/2014.July.24.26
Cloning, characterization, expression, and feeding response of thyrotropin receptor in largemouth bass (Micropterus salmoides)
Authors: Y.L. Gao, W. Song, L.L. Jiang, M.X. Mao, C.L. Wang, C.T. Ge and G.Y. Qian
Thyrotropin receptor (TSHR) is a G-protein-coupled receptor that regulates the synthesis, storage, and secretion of thyroid hormones in the thyroid tissue. The aims of the present study were to characterize the full-length TSHR cDNA in largemouth bass (Micropterus salmoides), and to determine the TSHR gene transcription levels in different tissues. In add.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038658
- DOI:
- 10.4238/gmr.15038658
Candidate genes for the development of hair follicles in Hu sheep
Authors: X.Y. Lv, R. Ni, W. Sun, R. Su, H.H. Musa, J.F. Yin, Q.Z. Wang, W. Gao and L. Chen
The aim of this study was to detect candidate genes for the development of hair follicles in the Hu sheep breed. Seven genes have been detected in large, medium, and small wave follicles of Hu sheep using gene chip technology. The histological features of the follicles of newborn Hu-lambs were combined with fluorescence quantitative PCR technology to dete.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036877
- DOI:
- 10.4238/gmr.15036877