Resveratrol
Coupled transcript and metabolite identification: insights on induction and synthesis of resveratrol in peanut, wild relatives and synthetic allotetraploid
Authors: P.A.S.V. Carvalho, A.C. Brasileiro, S. Leal-Bertioli, D.J. Bertioli, J.P. Silva, T.S. Agostini-Costa and M.A. Gimenes
Resveratrol is an antioxidant that is a promising antitumoral, cardioprotective and neuroprotective agent. It has been found in a restricted number of plants including peanut (Arachis hypogaea L.) and its wild relatives. The objective of this study was to understand the relationship between resveratrol content and the expressi.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039802
- DOI:
- 10.4238/gmr16039802
Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
Authors: J.W. Wu, J.J. Wang, J.B. Chen, Y.L. Huang, H. Wang, G.H. Liu,L.F. Li, M. Kang, X.G. Wang and H.H. Cai
Intervertebral disc degeneration is the main cause of lumbago disease, in which the extracellular matrix structure and moisture in the nucleus pulposus is lost continuously. In this study, we aimed to detect differential expression of silence mating type information regulation 2 homolog 1 (SIRT1) and matrix metalloproteinase-1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.5
- DOI:
- 10.4238/2015.October.16.5
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
Authors: X.S. Gu, Z.B. Wang, Z. Ye, J.P. Lei, L. Li, D.F. Su and X. Zheng
Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator (SIRT1), on cardiac function and AMPK expression in heart failure. Adult .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.17.17
- DOI:
- http://dx.doi.org/10.4238/2014.January.17.17
The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats
Authors: A.S. Yar, S. Menevse and E. Alp
Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.7
- DOI:
- 10.4238/2011.November.29.7
Inhibition of human chronic myelogenous leukemia K562 cell growth following combination treatment with resveratrol and imatinib mesylate
Authors: X.J. Wang and Y.H. Li
To investigate the effect of treatment with resveratrol combined with imatinib mesylate on human chronic myelogenous leukemia K562 cell growth inhibition and apoptosis, in vitro cultured human chronic myelogenous leukemia K562 cells were incubated with different concentrations of resveratrol and imatinib mesylate when the cells were in the logarithmic pha.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.17
- DOI:
- 10.4238/2015.June.11.17
Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells
Authors: J.P. Li, Q. Ma and C.M. Chen
This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 act.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017490
- DOI:
- 10.4238/gmr.15017490
Tristetraprolin: a novel mediator of the anticancer properties of resveratrol
Authors: C. Li, C. Tang and G. He
Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027213
- DOI:
- 10.4238/gmr.15027213