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Microbial Genetics   Research Article

Molecular combing in the analysis of developmentally regulated amplified segments of Bradysia hygida

Authors: K.J.R. Passos, S.Y. Togoro, S. Carignon, S. Koundrioukoff, A.-M. Lachages, M. Debatisse and M.A. Fernandez

Molecular combing technology is an important new tool for the functional and physical mapping of genome segments. It is designed to identify amplifications, microdeletions, and rearrangements in a DNA sequence and to study the process of DNA replication. This technique has recently been used to identify and analyze the dynamics of replication in amplified.. Read More»

Genet. Mol. Res. 11(3):
Microbial Genetics   Research Article

Cell cycle, DNA replication, repair, and recombination in the dimorphic human pathogenic fungus Paracoccidioides brasiliensis

Authors: Viviane Castelo Branco Reis, Fernando Araripe Gonçalves Torres, Marcio José Poças-Fonseca, Marlene Teixeira De-Souza, Diorge Paulo de Souza, João Ricardo Moreira Almeida, Camila Marinho-Silva, Nádia Skorupa Parachin, Alessandra da Silva Dantas, Thiago Machado Mello-de-Sousa and Lídia Maria Pepe de Moraes

DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essential information for understand.. Read More»

Genet. Mol. Res. 4(2):
Human Genetics   Research Article

Replication timing regulation in adults with chromosomal balance rearrangements

Authors: Y. Xie, J. Wu, S. Lin, Y. Zhou, Q. Fang and X. Sun

The alternative forms of the alleles in biallelic genes display a synchronous pattern of replication that is different from genes subjected to monoallelic expression, which exhibit an asynchronous mode of replication. The present study sought to gain insight into changes in the allele-specific replication timing in phenotypically normal humans with balanc.. Read More»

Genet. Mol. Res. 14(3):
Animal Genetics   Research Article

Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli

Authors: W. Wurihan, W. Wunier, H. Li, L.F. Fan and M. Morigen

The trans-translation pathway, mediated by the transfer messenger RNA (tmRNA; encoded by the ssrA gene) and the SmpB protein (tmRNA-binding protein expressed in Salmonella enterica), which is conserved in bacteria, is required for various cellular processes. A previous study has shown that trans-translation is required to ensu.. Read More»

Genet. Mol. Res. 15(3):
Medical Genetics   Research Article

Intrinsically bent DNA in replication origins and gene promoters

Authors: F. Gimenes, K.I. Takeda, A. Fiorini, F.S. Gouveia and M.A. Fernandez

Intrinsically bent DNA is an alternative conformation of the DNA molecule caused by the presence of dA/dT tracts, 2 to 6 bp long, in a helical turn phase DNA or with multiple intervals of 10 to 11 bp. Other than flexibility, intrinsic bending sites induce DNA curvature in particular chromosome regions such as replication origi.. Read More»

Genet. Mol. Res. 7(2):
Microbial Genetics   Short communication

DNA repair by polymerase δ in Saccharomyces cerevisiae is not controlled by the proliferating cell nuclear antigen-like Rad17/Mec3/Ddc1 complex

Authors: J.M. Cardone, M. Brendel and J.A.P. Henriques

DNA damage activates several mechanisms such as DNA repair and cell cycle checkpoints. The Saccharomyces cerevisiae heterotrimeric checkpoint clamp consisting of the Rad17, Mec3 and Ddc1 subunits is an early response factor to DNA damage and activates checkpoints. This complex is structurally similar to the proliferating cell nuclear antigen (PCNA), which.. Read More»

Genet. Mol. Res. 7(1):
Animal Genetics   Letter to the Editor

Drosha, DGCR8, and Dicer mRNAs are downregulated in human cells infected with dengue virus 4 - Genet. Mol. Res. 15 (2): gmr.15027891 Drosha, Dicer, and TRBP mRNA are downregulated in Vero cells with the 3 UTR of Dengue virus

Authors: J.A. Castillo and S. Urcuqui-Inchima

A recent paper (Casseb et al., 2016) published in the journal Genetics and Molecular Research described the interesting concept that dengue virus (DENV)-4 infection, in the human cell line A-549, leads to the downregulation of expression of key components of microRNA (miRNA) biogenesis, such as Drosha, Dicer, and DGCR8. For th.. Read More»

Genet. Mol. Res. 15(3):
Human Genetics   Research Article

Molecular docking of the anticancer bioactive compound proceraside with macromolecules involved in the cell cycle and DNA replication

Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, M. AbulFarah, F. Al-Hemaid, F.M. Abou-Tarboush, K.M. Al-Anazi, F.S.M. Al-Anazi and J. Lee

The bioactive compounds proceraside A, frugoside and calotropin, which were extracted from the root bark of Calotropis procera (Aiton) W.T. Aiton (family Asclepiadaceae), were recently reported to inhibit the growth of inhibition against various human cancer cell lines in vitro. However, their modes of action have not been cle.. Read More»

Genet. Mol. Res. 15(2):
Cytogenomics   Research Article

ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae

Authors: R. Matuo, F.G. Sousa, D. Bonatto, A.A. Mielniczki-Pereira, J. Saffi, D.G. Soares, A.E. Escargueil, A.K. Larsen and J.A.P. Henriques

Chromatin is thought to modulate access of repair proteins to DNA lesions, and may be altered by chromatin remodelers to facilitate repair. We investigated the participation of chromatin remodelers and DNA repair in 5-fluorouracil (5-FU) cytotoxicity in Saccharomyces cerevisiae. 5-FU is an antineoplastic drug commonly used in clinical settings. Among the .. Read More»

Genet. Mol. Res. 12(2):
Microbial Genetics   Research Article

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli

Authors: Y. Yao, Wunier and Morigen

Escherichia coli cells have dozens of two-component systems to sense and respond to various stimuli, and thereby cope with changing environments. BaeS/BaeR is one such two-component system, and it deals with a variety of envelope stresses. Interestingly, the ArcA/ArcB and TorS/TorR two-component systems are known to be associated with initiation of DNA re.. Read More»

Genet. Mol. Res. 14(4):


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