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Human Genetics   Research Article

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

Authors: W.G. Zhong, Y. Wang, H. Zhu and X. Zhao

Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences i.. Read More»

Genet. Mol. Res. 11(3):
Human Genetics   Research Article

Expression and significance of the imprinted gene PEG10 in placenta of patients with preeclampsia

Authors: X.Y. Liang, X. Chen, Y.Z. Jin, X.O. Chen and Q.Z. Chen

The aim of this study was to investigate the expression and significance of the imprinted gene PEG10 (paternally expressed gene 10) in preeclampsia placental tissue. Quantitative real-time reverse transcriptase polymerase chain reaction and immunohistochemistry to evaluate mRNA and protein expression and distribution of PEG10 in placental tissues obtained.. Read More»

Genet. Mol. Res. 13(4):
Human Genetics   Research Article

Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia

Authors: D.M. Fan, Y. Wang, X.L. Liu, A. Zhang and Q. Xu

Preeclampsia is a common condition unique to pregnant women. Previous studies have suggested that several cytokines may contribute to defective placental invasion and endothelial damage in this condition. We investigated the influence of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C, -597G/A, an.. Read More»

Genet. Mol. Res. 16(1):
Human Genetics   Research Article

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

Authors: A. Sandoval-Carrillo, M. Aguilar-Duran, F. Vázquez-Alaniz,F.X. Castellanos-Juárez, M. Barraza-Salas, E. Sierra-Campos, A. Téllez-Valencia O. La Llave-León and J.M. Salas-Pacheco

Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutat.. Read More»

Genet. Mol. Res. 13(1):
Medical Genetics   Research Article

Serum microRNA expression in pregnancies with preeclampsia

Authors: T. Gunel, Y.G. Zeybek, P. Akçakaya, I. Kalelioğlu, A. Benian, H. Ermis and K. Aydınlı

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circul.. Read More»

Genet. Mol. Res. 10(4):
Human Genetics   Research Article

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese womenc

Authors: H. Lin, Z. Yin, X.Y. Yu, N. Lin, Y. Lin, J. Chen, Y.Z. Chen, K.P. Lu and H.K. Liu

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) w.. Read More»

Genet. Mol. Res. 13(3):
Medical Genetics   Research Article

High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia

Authors: S. Wang, F.Y. Qiao and L. Feng

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656.. Read More»

Genet. Mol. Res. 12(3):
Human Genetics   Research Article

Common variant rs7579169 is associated with preeclampsia in Han Chinese women

Authors: L.F. Guo, Z.H. Wang and Y.F. Wang

As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP.. Read More»

Genet. Mol. Res. 15(2):
Bioinformatics   Research Article

Partial least squares-based gene expression analysis in preeclampsia

Authors: F. Jiang, Y. Yang, J. Li, W. Li, Y. Luo, Y. Li, H. Zhao, X. Wang, G. Yin and G. Wu

Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloa.. Read More»

Genet. Mol. Res. 14(2):
Human Genetics   Research Article

Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia

Authors: Q.Y. Liu, F.Y. Gao, X.R. Liu, J. Li, M. Ji, J. Dong and X.T. Wang

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in .. Read More»

Genet. Mol. Res. 14(4):