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Medical Genetics   Research Article

Hydrogen peroxide enhances the uptake of polyethylenimine/oligonucleotide complexes in A549 cells by activating CaMKII independent of [Ca2+]c elevation

Authors: Z. Ma, W.W. Sun and X. Wang

Aerosol oligonucleotide therapy has vast potential in pulmonary system diseases. Reactive oxygen species (ROS) play an important role in complex physiological processes such as cell signaling, apoptosis, etc. Therefore, to determine the mechanism of ROS involvement in polyethylenimine/oligonucleotide (PEI/ON) endocytosis in ce.. Read More»

Genet. Mol. Res. 13(2):
2014.February.21.15
DOI:
10.4238/2014.February.21.15

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