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Role of PPAR�± in down-regulating AGE-induced TGF-�² and MMP-9 expressions in chondrocytes
Authors: J. Wang, G. Wang and G.W. Sun
Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogres.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027963
- DOI:
- 10.4238/gmr.15027963
Decreased levels of soluble receptor for advanced glycation end-products in aortic valve calcification patients
Authors: H. Zheng,Y. Li,N. Xie,J.L. Huang,H.F. Xu and M. Luo
The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aorti.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.6
Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer
Authors: Q. Xu, Y.Y. Ding, L.X. Song andJ.F. Xu
The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. The allelic frequencies of the UGT1A1 and ERCC1 variants in a group of 89 patients with advanced ovarian cancer were determined.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.17
- DOI:
- 10.4238/2015.June.29.17
Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling
Authors: H.G. Zhang, R.X. Wang, L.L. Li, W.T. Sun, H.Y. Zhang and R.Z. Liu
Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from nort.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.28
- DOI:
- 10.4238/2015.December.28.28
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19