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Mycophenolate Mofetil

Human Genetics   Research Article

Study on the association of UGT1A9 gene c.98T>C polymorphism and mycophenolic acid plasma levels in renal transplant patients

Authors: L.R. Ruschel, V.M. Schmitt, A.B. Silva, C.S.A. Oliveira, K. Flach, D.O. d�Avila and F.V. Thiesen

Mycophenolate mofetil (MMF) is a prodrug active only after its hydrolysis to mycophenolic acid (MPA). The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms (SNPs) in the UGT1A9 gene may be responsible for individual differences in the pharma.. Read More»

Genet. Mol. Res. 16(2):
gmr16029598
DOI:
10.4238/gmr16029598
Human Genetics   Research Article

Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells

Authors: F.Q. Chen, Q.Y. Wang, G.Z. Wei, X.Y. Ma, D.W. Ma, W.W. Deng and W.B. Sun

The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Cultured HMCs were divided into.. Read More»

Genet. Mol. Res. 13(2):
2014.April.17.11
DOI:
10.4238/2014.April.17.11