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Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Plant Genetics   Research Article

Expression profile analysis reveals putative prostate cancer-related microRNAs

Authors: H. Song1*, Y. Liu2*, J. Pan3 and S.T. Zhao1

Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abn.. Read More»

Genet. Mol. Res. 12(4):
2013.October.24.4
DOI:
10.4238/2013.October.24.4
Medical Genetics   Research Article

Detection of CK19, LUNX, and KS1/4 mRNA expression in the peripheral blood for diagnosis of micrometastases in patients with non-small cell lung cancer and their clinical implications

Authors: L. Yan, Y. Yao, L.H. Wang, M.L. Wang and X.H. Fu

The expression of CK19, LUNX, and KS1/4 mRNA biomarkers was detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients to investigate the feasibility of indicating lung cancer micrometastases. Micrometastases were identified in the peripheral blood of 32 NSCLC patients, 15 benign pulmonar.. Read More»

Genet. Mol. Res. 14(4):
2015.November.24.17
DOI:
10.4238/2015.November.24.17
Bioinformatics   Research Article

Effects of lipopolysaccharide on the stearoyl-coenzyme A desaturase mRNA level in bovine primary hepatic cells

Authors: Q.D. Jiang, H.P. Li, F.J. Liu, X.J. Wang, Y.J. Guo, L.F. Wang, W.F. Lu, H.J. Li, X.P. Li and Y.Y. Wang

This study aimed to compare the effects of lipopolysaccharide (LPS) on stearoyl-coenzyme A desaturase (SCD) gene expression in mouse primary hepatic cells. To obtain sufficient total RNA, primary hepatic cells were plated on 6-cm diameter-type collagen 1-coated dishes (1 x 106 cells per dish). The test was divided into 6 group.. Read More»

Genet. Mol. Res. 13(2):
2014.January.24.12
DOI:
10.4238/2014.January.24.12
Human Genetics   Research Article

Eosinophil cationic protein mRNA expression in children with bronchial asthma

Authors: H.Y. Yu1, X.Y. Li2, Z.F. Cai1, L. Li3, X.Z. Shi4, H.X. Song5 and X.J. Liu1

Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 .. Read More»

Genet. Mol. Res. 14(4):
2015.November.13.11
DOI:
10.4238/2015.November.13.11
Animal Genetics   Research Article

Molecular characterization, expression, polymorphism of NR5A2 and its relationship with litter size in Hu sheep

Authors: Y.X. Li, J. Zhang, Y. Qian, C.H. Meng, H.L. Wang, X.J. Tao, S. Zhong, S.X. Cao and Q.F. Li

NR5A2 has been implicated in processes as diverse as steroidogenesis, cellular proliferation, ovarian follicular development, ovulation, and fertility in mammals. However, data about the relationship between NR5A2 and prolificacy in mammals are lacking. In the present study, we identified and characterized NR5A2 of Hu sheep, a.. Read More»

Genet. Mol. Res. 14(4):
2015.October.19.20
DOI:
10.4238/2015.October.19.20
Animal Genetics   Research Article

PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle

Authors: W. Qin, C.N. Liang, X. Guo, M. Chu, J. Pei, P.J. Bao, X.Y. Wu, T.K. Li and P. Yan

ntramuscular fatty acid (FA) is related to meat qualities such as juiciness, tenderness, palatability, and shear force. PPARα plays an important role in lipid metabolism in the liver and skeletal muscle. This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARα signal pathway genes as .. Read More»

Genet. Mol. Res. 14(4):
2015.November.18.9
DOI:
10.4238/2015.November.18.9
Plant Genetics   Research Article

Expression patterns of Doppel in differential ovine PRNP genotypes: quantification using real-time RT-PCR

Authors: C. Wang, C.-L. Zhao, L. Liu, R. Wu and X.-L. Zhang

Doppel is a homologue of cellular prion protein (PrP)-like protein (PrPC). Different tissue samples were collected from the central nervous system plus four regions of lymphoid system, eleven regions of digestive tract and two reproductive organs from four ARR/ARQ and four ARH/ARQ sheep, genotypes of the PrP gene. Total RNA wa.. Read More»

Genet. Mol. Res. 14(4):
2015.October.9.3
DOI:
10.4238/2015.October.9.3
Microbial Genetics   Research Article

Characterization and bacterial-binding activity of a novel C-type lectin from the red-spotted grouper, Epinephelus akaara

Authors: Z.W. Zhang X.F. Shi M. Qu S.X. Ding

Because of their specific binding to carbohydrates, lectins play a crucial role in pathogen recognition and clearance in vertebrate animals. Previously, only two types of collectins had been isolated from bony fish: mannan-binding lectin (MBL) and galactose-binding lectin (GalBL). We sequenced a novel collectin (designated EALec1) from the red-spotted gro.. Read More»

Genet. Mol. Res. 11(3):
2012.May.11.1
DOI:
10.4238/2012.May.11.1

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