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Cytogenomics   Research Article

Tissue-specific adaptive levels of glucocorticoid receptor alpha mRNA and their relationship with insulin resistance

Authors: R.B. Castro C.A. Longui C.D.C. Faria T.S. Silva F. Richeti M.N. Rocha M.R. Melo W.L. Pereira E.G. Chamlian L.A. Rivetti

Insulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases. Glucocorticoids are known determinant factors of insulin resistance. We quantified glucocorticoid receptor alpha (GRα) mRNA and 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mRNA in various tissues of 35 patients with previously established card.. Read More»

Genet. Mol. Res. 11(4):
2012.November.21.1
DOI:
10.4238/2012.November.21.1
Human Genetics   Research Article

Association of KCNJ11 with impaired glucose regulation in essential hypertension

Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu

KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»

Genet. Mol. Res. 10(2):
vol10-2gmr1127
DOI:
10.4238/vol10-2gmr1127