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Plant Genetics   Research Article

Genetic damage in Mexican and South American sweet corn varieties due to the use of herbicides (Nicosulfuron and Topramezone)

Authors: M.S. Reynoso, C.M. Alvarez, L.L. De la Cruz, J.F.G. Landeros, J.J.G. Sánchez, A.R.A. Villalobos

In order to encourage corn production, several herbicides such as nicosulfuron and topramezone are used. Though they offer great advantages, they may affect crop productivity and may even induce DNA damage. This study evaluated genotoxic activity at two nicosulfuron concentrations (40,000 and 80, 000 ppm) and at four topramezone concentrations (1480, 148,.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039921
DOI:
http://dx.doi.org/10.4238/gmr16039921
Medical Genetics   Research Article

Anthocyanins-loaded Eudragit® L100 nanoparticles: in vitro cytotoxic and genotoxic analysis

Authors: TB de Queiroz, D Dupeyrón, JCT Carvalho, IOM Gaivão, and EL Maistro

Anthocyanins are flavonoids compounds that have a great therapeutic potential acting as antioxidants, anti-inflammatory and anti-carcinogenic agents. They are consumed through food, pharmaceutical and cosmetics industries as a natural alternative to synthetic dyes. However, anthocyanins are unstable depending on pH, temperatur.. Read More»

Genet. Mol. Res. 17(1):
gmr16039875
DOI:
10.4238/gmr16039875
Microbial Genetics   Research Article

Cellular responses induced in vitro by pestheic acid, a fungal metabolite, in a gastric adenocarcinoma cell line (PG100)

Authors: J.M.C. Sousa, L.A. Matos, D.F.A. Alcântara, H.F. Ribeiro, L.S. Santos, M.N. Oliveira, L.C. Brito-Junior, A.S. Khayat, A.C. Guimarães, L.A. Cunha, R.R. Burbano and M.O. Bahia

There is a constant search for new cancer treatments that are less aggressive and economically affordable. In this context, natural products extracted from plants, fungi, and microorganisms are of great interest. Pestheic acid, or dihidromaldoxin, is a chlorinated diphenylic ether extracted from the phytopathogenic fungus Pestalotiopsis guepinii (Amphisph.. Read More»

Genet. Mol. Res. 12(4):
2013.October.1.1
DOI:
10.4238/2013.October.1.1
Human Genetics   Research Article

Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin

Authors: R.J. Oliveira, E.S. Sassaki, A.C.D. Monreal, M.T.F.D. Monreal,J.R. Pesarini, M.O. Mauro, R. Matuo, A.F. Silva, N.N. Zobiole,J.M. Siqueira, L.R. Ribeiro, M.S. Mantovani

Cisplatin is an effective antineoplastic drug. However, it provokes considerable collateral effects, including genotoxic and clastogenic activity. It has been reported that a diet rich in glutamine can help inhibit such collateral effects. We evaluated this activity in 40 Swiss mice, distributed into eight experimental groups:.. Read More»

Genet. Mol. Res. 12(4):
2013.December.2.2
DOI:
10.4238/2013.December.2.2
Plant Genetics   Research Article

Induced mitotic homologous recombination by the babesicide imidocarb dipropionate in Aspergillus nidulans diploid cells

Authors: P.A.S.R. Santos, J.R. Sant’Anna, C.C.S. Franco, L.J. Rosada, G.N.M. Esquissato and M.A.A. Castro-Prado

Imidocarb dipropionate (IMD) is a chemotherapeutic agent prescribed for the treatment and control of babesiosis; it is known to be a nucleic acid synthesis inhibitor. Although it is an effective babesicide, there are reports of persistent IMD residues retained at high levels in edible tissues of cattle, swine and sheep, raising concerns about potential ef.. Read More»

Genet. Mol. Res. 11(3):
2012.July.6.1
DOI:
10.4238/2012.July.6.1
Plant Genetics   Research Article

Assessing the genotoxicities of sparteine and compounds isolated from Lupinus mexicanus and L. montanus seeds by using comet assay

Authors: M.R. Silva, C.M. Alvarez, P.M. García and M.A. Ruiz

The genus Lupinus is widely distributed. Its seeds are used for animal and human food, and Lupinus possesses pharmacological potential because of its high content of quinolizidine alkaloids and flavonoids; however, there is little available information about its genotoxicity. We used the comet assay and staminal nuclei of Tradescantia (clone 4430) to eval.. Read More»

Genet. Mol. Res. 13(4):
2014.December.12.12
DOI:
10.4238/2014.December.12.12
Human Genetics   Research Article

The radiotracer 99mTc-MIBI is not genotoxic for human peripheral blood lymphocytes at diagnostic radioactive dose

Authors: S.J. Hosseinimehr1, A. Ahmadi1, D. Beiki2, A. Mahmoudzadeh3, M. Babaei4 and E. Habibi1

The radiotracer technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) has been widely used for myocardial blood flow imaging. We investigated the genotoxicity of 99mTc-MIBI in cultured human lymphocytes at the same concentration used in patients. Radioactivity doses were determined in whole blood at 5 min post-injection of 20 mCi 99mTc-MIBI in patients. .. Read More»

Genet. Mol. Res. 8(3):
vol8-3gmr602
DOI:
10.4238/vol8-3gmr602
Human Genetics   Research Article

Protective effects of β-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

Authors: C.D. Dias, B.C. Araújo, E.S. Dutra and J.C. Nepomuceno

β-carotene (BC), pro-vitamin A, is an efficient antioxidant, effective in the neutralization of oxygen reactive species, which cause serious damage to DNA. Various studies have been conducted on the effectiveness of BC for chemoprevention of cancer and heart disease. Doxorubicin is a chemotherapeutic agent used for cancer.. Read More»

Genet. Mol. Res. 8(4):
vol8-4gmr626
DOI:
10.4238/vol8-4gmr626
Medical Genetics   Research Article

Aspergillus nidulans as a biological system to detect the genotoxic effects of mercury fumes on eukaryotes

Authors: G.D. Sousa, T.D. Zucchi, F.D. Zucchi, R.G. Miller1, R.M.A. Anjos,P. Poli and T.M.A.D. Zucchi

Mercury (Hg) pollution is one of the most serious environmental problems. Due to public concern prompted by the symptoms displayed by people who consumed contaminated fish in Minamata, Japan in 1956, Hg pollution has since been kept under constant surveillance. However, despite considerable accumulation of knowledge on the nox.. Read More»

Genet. Mol. Res. 8(2):
vol8-2gmr587
DOI:
10.4238/vol8-2gmr587
Animal Genetics   Research Article

N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes

Authors: C.A.F. Aiub, G. Gadermaier, I.O. Silva, I. Felzenszwalb, L.F.R. Pinto, F. Ferreira and P. Eckl

In rats, N-nitrosodiethylamine (NDEA) induces tumors mainly in the liver. This could be because various enzymes are responsible for the metabolic activation of NDEA, besides the hepatic NDEA metabolizing enzyme, CYP2E1. We examined NDEA genotoxicity and cytotoxicity in primary cultures of female rat hepatocytes; we also looked.. Read More»

Genet. Mol. Res. 10(4):
2011.October.5.4
DOI:
10.4238/2011.October.5.4