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Genetic Association

Human Genetics   Research Article

Predominance of the A allele but no association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes in a Nigerian population

Authors: Godwill Azeh Engwa, Friday Nweke Nwalo, Chosen E. Obi, Christie Onyia, Opeolu Oyejide Ojo Wilfred Fon Mbacham, Benjamin Ewa Ubi

Though the rs5219 E23K variant of the KCNJ11 gene is commonly known to be associated with Type 2 diabetes (T2D) in Caucasian and Asian populations, little or none of such findings have been revealed in Nigeria. Hence, this study was aimed to assess the relationship between E23K polymorphic variant of the KCNJ11 gene and T2D in.. Read More»

Genet. Mol. Res. 17(1):
gmr16039889
DOI:
10.4238/gmr16039889
Animal Genetics   Research Article

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Authors: W. Cai, Z.T. Wang, J. Zhong and Y. Zhang

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the all.. Read More»

Genet. Mol. Res. 12(4):
2013.April.26.1
DOI:
10.4238/2013.April.26.1
Human Genetics   Research Article

Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women

Authors: Z.S. ��zkan, D. Deveci, E. ��nalan Etem and H. Y�¼ce

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women wi.. Read More»

Genet. Mol. Res. 9(4):
vol9-4gmr922
DOI:
10.4238/vol9-4gmr922
Animal Genetics   Research Article

Heritabilities and genetic correlations for reproductive traits in an F2 reciprocal cross chicken population

Authors: R.P. Savegnago, M.E. Buzanskas, B.N. Nunes, S.B. Ramos, M.C. Ledur, K. Nones and D.P. Munari

Studies estimating genetic parameters for reproductive traits in chickens can be useful for understanding and improvement of their genetic architecture. A total of 1276 observations of fertility (FERT), hatchability of fertile eggs (HFE) and hatchability of total eggs (HTE) were used to estimate the genetic and phenotypic para.. Read More»

Genet. Mol. Res. 10(3):
vol10-3gmr1053
DOI:
10.4238/vol10-3gmr1053
Human Genetics   Research Article

Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population

Authors: F.F. Yang Y. Huang Q.B. Li J.H. Dai Z. Fu

Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with childhood asthma in a Chinese population. Genomic DNA was extracted f.. Read More»

Genet. Mol. Res. 11(4):
2012.October.19.1
DOI:
10.4238/2012.October.19.1
Human Genetics   Research Article

Association between BMP-2 and COL6A1 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the cervical spine in Korean patients and family members

Authors: K.H. Kim, S.U. Kuh, J.Y. Park, S.J. Lee, H.S. Park, D.K. Chin, K.S. Kim and Y.E. Cho

COL6A1 and BMP-2 genes have been implicated in ossification of the posterior longitudinal ligament (OPLL) susceptibility in Japanese and Chinese Han populations. However, no study has yet investigated the DNA of unaffected family members of patients with OPLL. This study investigated differences in genetic polymorphisms of BMP.. Read More»

Genet. Mol. Res. 13(1):
2014.March.31.4
DOI:
10.4238/2014.March.31.4
Microbial Genetics   Research Article

Effect of two single nucleotide polymorphisms on milk yield and composition

Authors: J.C. Rinc�³n, A. L�³pez-Herrera and J.J. Echeverri

The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and some economically important character.. Read More»

Genet. Mol. Res. 12(2):
2013.April.2.15
DOI:
10.4238/2013.April.2.15